Enantioselective Preparation of 2‐Aminomethyl Carboxylic Acid Derivatives: Solving the β 2 ‐Amino Acid Problem with the Chiral Auxiliary 4‐Isopropyl‐5,5‐diphenyloxazolidin‐2‐one (DIOZ). Preliminary Communication

• Published in: Helvetica chimica acta Vol. 86; no. 6; pp. 1852 - 1861
• Main Authors: Seebach, Dieter, Schaeffer, Laurent, Gessier, François, Bindschädler, Pascal, Jäger, Corinna, Josien, Delphine, Kopp, Sascha, Lelais, Gérald, Mahajan, Yogesh R., Micuch, Peter, Sebesta, Radovan, Schweizer, Bernd W.
• Format: Journal Article
• Language: English
• Published: 01.06.2003

Abstract Multigram amounts of suitably protected β 2 ‐amino acids with 17 of the 20 proteinogenic side chains are prepared by diastereoselective reactions of Li, B, or Ti enolates of the corresponding 3‐acyl‐4‐isopropyl‐5,5‐diphenyloxazolidin‐2‐ones (acyl‐DIOZ; 1 ) with appropriate electrophiles (am...