Nasopharyngeal Epstein-Barr Virus Load: An Efficient Supplementary Method for Population-Based Nasopharyngeal Carcinoma Screening

• Published in: PloS one Vol. 10; no. 7; p. e0132669
• Main Authors: Chen, Yufeng, Zhao, Weilin, Lin, Longde, Xiao, Xue, Zhou, Xiaoying, Ming, Huixin, Huang, Tingting, Liao, Jian, Li, Yancheng, Zeng, Xiaoyun, Huang, Guangwu, Ye, Weimin, Zhang, Zhe
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.07.2015; Public Library of Science (PLoS)
• Subjects: Adult; Analysis; Antibodies; Antigens; Antigens, Viral - immunology; Area Under Curve; Assaying; Biopsy; Cancer; Capsid - immunology; Carcinoma; China - epidemiology; Deoxyribonucleic acid; Diagnostic systems; DNA; DNA, Viral - blood; Early Detection of Cancer - methods; Education; Endoscopy; Epidemiology; Epstein-Barr virus; Female; Females; Genomes; Herpesvirus 4, Human - immunology; Herpesvirus 4, Human - physiology; Hospitals; Humans; Immunoglobulin A; Immunoglobulins; Laboratories; Male; Males; Medical diagnosis; Medical research; Medicin och hälsovetenskap; Methods; Middle Aged; Multivariate Analysis; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms - blood; Nasopharyngeal Neoplasms - diagnosis; Nasopharyngeal Neoplasms - immunology; Nasopharyngeal Neoplasms - virology; Nasopharynx; Otolaryngology; Population; Population studies; Population-based studies; Prevention; Public health; Quantitative analysis; Risk; Risk Factors; Risk groups; Screening; Studies; Surgery; Throat cancer; Viral Load - immunology; Viruses; China

Serological detection of Epstein-Barr virus (EBV) antibodies is frequently used in nasopharyngeal carcinoma (NPC) mass screening. However, the large number of seropositive subjects who require close follow-up is still a big burden. The present study aimed to detect the nasopharyngeal EBV load in a h...