High prevalence of human cytomegalovirus proteins and nucleic acids in primary breast cancer and metastatic sentinel lymph nodes

• Published in: PloS one Vol. 8; no. 2; p. e56795
• Main Authors: Taher, Chato, de Boniface, Jana, Mohammad, Abdul-Aleem, Religa, Piotr, Hartman, Johan, Yaiw, Koon-Chu, Frisell, Jan, Rahbar, Afsar, Söderberg-Naucler, Cecilia
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.02.2013; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Angiogenesis; Binding sites; Biology; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - virology; Breastfeeding & lactation; Cancer; Cell cycle; Chemokines; Cytomegalovirus; Cytomegalovirus - genetics; Cytomegalovirus - metabolism; Cytomegalovirus - pathogenicity; Cytomegalovirus infections; Deoxyribonucleic acid; DNA; Estrogens; Female; Gene expression; Hospitals; Humans; Immunohistochemistry; Immunology; In Vitro Techniques; Infection; Infections; Inflammation; Kinases; Lymph nodes; Lymph Nodes - metabolism; Lymph Nodes - virology; Lymphatic system; Medical prognosis; Medical research; Medicin och hälsovetenskap; Medicine; Metastases; Metastasis; Middle Aged; Nucleic acids; Oncology; Paraffin; Pathogenesis; Patients; Progesterone; Proteins; Real-Time Polymerase Chain Reaction; Sentinel Lymph Node Biopsy; Statistical analysis; Statistical methods; Tumorigenesis; Viral infections; Viral Proteins - genetics; Viral Proteins - metabolism; Sweden

Breast cancer is a leading cause of death among women worldwide. Increasing evidence implies that human cytomegalovirus (HCMV) infection is associated with several malignancies. We aimed to examine whether HCMV is present in breast cancer and sentinel lymph node (SLN) metastases. Formalin-fixed para...