Enhanced neonatal Fc receptor function improves protection against primate SHIV infection

• Published in: Nature (London) Vol. 514; no. 7524; pp. 642 - 645
• Main Authors: Ko, Sung-Youl, Pegu, Amarendra, Rudicell, Rebecca S., Yang, Zhi-yong, Joyce, M. Gordon, Chen, Xuejun, Wang, Keyun, Bao, Saran, Kraemer, Thomas D., Rath, Timo, Zeng, Ming, Schmidt, Stephen D., Todd, John-Paul, Penzak, Scott R., Saunders, Kevin O., Nason, Martha C., Haase, Ashley T., Rao, Srinivas S., Blumberg, Richard S., Mascola, John R., Nabel, Gary J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.10.2014; Nature Publishing Group
• Subjects: 631/250; Administration, Rectal; Animals; Antibodies; Antibodies, Neutralizing - analysis; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - genetics; Antibodies, Neutralizing - immunology; Antibodies, Viral - analysis; Antibodies, Viral - blood; Antibodies, Viral - genetics; Antibodies, Viral - immunology; Antibody Affinity - genetics; Antibody Affinity - immunology; Antibody-Dependent Cell Cytotoxicity - immunology; Binding Sites - genetics; CD4 Antigens - metabolism; Cell receptors; Cytotoxicity; Fc receptors; Female; Half-Life; Health aspects; Histocompatibility Antigens Class I - immunology; HIV; HIV - chemistry; HIV - immunology; HIV Antibodies - analysis; HIV Antibodies - blood; HIV Antibodies - genetics; HIV Antibodies - immunology; HIV Envelope Protein gp160 - chemistry; HIV Envelope Protein gp160 - immunology; HIV Infections - immunology; HIV Infections - prevention & control; Human immunodeficiency virus; Humanities and Social Sciences; Immunity, Mucosal - immunology; Immunization; Immunization, Passive; Infection; Intestinal Mucosa - immunology; letter; Macaca mulatta; Male; Mice; multidisciplinary; Mutagenesis, Site-Directed; Mutation; Physiological aspects; Physiology; Prevention; Primates; Protein research; Receptors, Fc - immunology; Receptors, IgG - immunology; Receptors, IgG - metabolism; Rectum - immunology; Science; Simian Acquired Immunodeficiency Syndrome - immunology; Simian Acquired Immunodeficiency Syndrome - prevention & control; Simian immunodeficiency virus; Simian Immunodeficiency Virus - immunology; T cell receptors; Transcytosis; Viral antibodies; Viral infections; Virus diseases; United States

A mutation in VRC01, a broadly neutralizing, HIV-1-specific antibody, confers enhanced binding to the neonatal Fc receptor, increasing the antibody half-life in the serum and localization in mucosal tissues, where it provides superior protection against rectal simian HIV-1 infection in macaques. Enh...