LF4/MOK and a CDK-related kinase regulate the number and length of cilia in Tetrahymena

• Published in: PLoS genetics Vol. 15; no. 7; p. e1008099
• Main Authors: Jiang, Yu-Yang, Maier, Wolfgang, Baumeister, Ralf, Minevich, Gregory, Joachimiak, Ewa, Wloga, Dorota, Ruan, Zheng, Kannan, Natarajan, Bocarro, Stephen, Bahraini, Anoosh, Vasudevan, Krishna Kumar, Lechtreck, Karl, Orias, Eduardo, Gaertig, Jacek
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 24.07.2019; Public Library of Science (PLoS)
• Subjects: Basal bodies; Biochemistry; Bioinformatics; Biology and Life Sciences; Cellular biology; Cilia; Cilia - metabolism; Cyclin-dependent kinase; Cyclin-Dependent Kinases - metabolism; Funding; Gene Expression Regulation; Genetic aspects; Genetic screening; Genomes; Kinases; Laboratories; Locomotion; Medicine and Health Sciences; Mitogen-Activated Protein Kinases - metabolism; Mutation; Phosphorylation; Phosphotransferases; Physiological aspects; Proteins; Protozoan Proteins - metabolism; Research and Analysis Methods; Supervision; Tetrahymena; Tetrahymena - cytology; Tetrahymena - metabolism; Tetrahymena - physiology; United States; New York; Santa Barbara California; United States > US; Poland; Georgia; California; Germany

The length of cilia is controlled by a poorly understood mechanism that involves members of the conserved RCK kinase group, and among them, the LF4/MOK kinases. The multiciliated protist model, Tetrahymena, carries two types of cilia (oral and locomotory) and the length of the locomotory cilia is de...