Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Blood concentrations of lipoproteins and lipids are heritable 1 risk factors for cardiovascular disease 2 , 3 . Using genome-wide association data from three studies ( n = 8,816 that included 2,758 individuals from the Diabetes Genetics Initiative specific to the current paper as well as 1,874 indiv...
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| Published in | Nature genetics Vol. 40; no. 2; pp. 189 - 197 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.02.2008
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1061-4036 1546-1718 1546-1718 |
| DOI | 10.1038/ng.75 |
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| Abstract | Blood concentrations of lipoproteins and lipids are heritable
1
risk factors for cardiovascular disease
2
,
3
. Using genome-wide association data from three studies (
n
= 8,816 that included 2,758 individuals from the Diabetes Genetics Initiative specific to the current paper as well as 1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables reported in a companion paper in this issue
4
) and targeted replication association analyses in up to 18,554 independent participants, we show that common SNPs at 18 loci are reproducibly associated with concentrations of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and/or triglycerides. Six of these loci are new (
P
< 5 × 10
−8
for each new locus). Of the six newly identified chromosomal regions, two were associated with LDL cholesterol (1p13 near
CELSR2
,
PSRC1
and
SORT1
and 19p13 near
CILP2
and
PBX4
), one with HDL cholesterol (1q42 in
GALNT2
) and five with triglycerides (7q11 near
TBL2
and
MLXIPL
, 8q24 near
TRIB1
, 1q42 in
GALNT2
, 19p13 near
CILP2
and
PBX4
and 1p31 near
ANGPTL3
). At 1p13, the LDL-associated SNP was also strongly correlated with
CELSR2
,
PSRC1
, and
SORT1
transcript levels in human liver, and a proxy for this SNP was recently shown to affect risk for coronary artery disease
5
. Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care. |
|---|---|
| AbstractList | Blood concentrations of lipoproteins and lipids are heritable
1
risk factors for cardiovascular disease
2
,
3
. Using genome-wide association data from three studies (
n
= 8,816 that included 2,758 individuals from the Diabetes Genetics Initiative specific to the current paper as well as 1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables reported in a companion paper in this issue
4
) and targeted replication association analyses in up to 18,554 independent participants, we show that common SNPs at 18 loci are reproducibly associated with concentrations of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and/or triglycerides. Six of these loci are new (
P
< 5 × 10
−8
for each new locus). Of the six newly identified chromosomal regions, two were associated with LDL cholesterol (1p13 near
CELSR2, PSRC1
and
SORT1
and 19p13 near
CILP2
and
PBX4
), one with HDL cholesterol (1q42 in
GALNT2
) and five with triglycerides (7q11 near
TBL2
and
MLXIPL
, 8q24 near
TRIB1
, 1q42 in
GALNT2
, 19p13 near
CILP2
and
PBX4
and 1p31 near
ANGPTL3
). At 1p13, the LDL-associated SNP was also strongly correlated with
CELSR2, PSRC1
, and
SORT1
transcript levels in human liver, and a proxy for this SNP was recently shown to affect risk for coronary artery disease
5
. Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care. Blood concentrations of lipoproteins and lipids are heritable super(1) risk factors for cardiovascular disease super(3). Using genome-wide association data from three studies (n = 8,816 that included 2,758 individuals from the Diabetes Genetics Initiative specific to the current paper as well as 1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables reported in a companion paper in this issue super(4)) and targeted replication association analyses in up to 18,554 independent participants, we show that common SNPs at 18 loci are reproducibly associated with concentrations of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and/or triglycerides. Six of these loci are new (P < 5 [math] 10 super(-8) for each new locus). Of the six newly identified chromosomal regions, two were associated with LDL cholesterol (1p13 near CELSR2, PSRC1 and SORT1 and 19p13 near CILP2 and PBX4), one with HDL cholesterol (1q42 in GALNT2) and five with triglycerides (7q11 near TBL2 and MLXIPL, 8q24 near TRIB1, 1q42 in GALNT2, 19p13 near CILP2 and PBX4 and 1p31 near ANGPTL3). At 1p13, the LDL-associated SNP was also strongly correlated with CELSR2, PSRC1, and SORT1 transcript levels in human liver, and a proxy for this SNP was recently shown to affect risk for coronary artery disease super(5). Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care. Blood concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular disease. Using genome-wide association data from three studies (n = 8,816 that included 2,758 individuals from the Diabetes Genetics Initiative specific to the current paper as well as 1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables reported in a companion paper in this issue) and targeted replication association analyses in up to 18,554 independent participants, we show that common SNPs at 18 loci are reproducibly associated with concentrations of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and/or triglycerides. Six of these loci are new (P < 5 x 10(-8) for each new locus). Of the six newly identified chromosomal regions, two were associated with LDL cholesterol (1p13 near CELSR2, PSRC1 and SORT1 and 19p13 near CILP2 and PBX4), one with HDL cholesterol (1q42 in GALNT2) and five with triglycerides (7q11 near TBL2 and MLXIPL, 8q24 near TRIB1, 1q42 in GALNT2, 19p13 near CILP2 and PBX4 and 1p31 near ANGPTL3). At 1p13, the LDL-associated SNP was also strongly correlated with CELSR2, PSRC1, and SORT1 transcript levels in human liver, and a proxy for this SNP was recently shown to affect risk for coronary artery disease. Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care.Blood concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular disease. Using genome-wide association data from three studies (n = 8,816 that included 2,758 individuals from the Diabetes Genetics Initiative specific to the current paper as well as 1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables reported in a companion paper in this issue) and targeted replication association analyses in up to 18,554 independent participants, we show that common SNPs at 18 loci are reproducibly associated with concentrations of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and/or triglycerides. Six of these loci are new (P < 5 x 10(-8) for each new locus). Of the six newly identified chromosomal regions, two were associated with LDL cholesterol (1p13 near CELSR2, PSRC1 and SORT1 and 19p13 near CILP2 and PBX4), one with HDL cholesterol (1q42 in GALNT2) and five with triglycerides (7q11 near TBL2 and MLXIPL, 8q24 near TRIB1, 1q42 in GALNT2, 19p13 near CILP2 and PBX4 and 1p31 near ANGPTL3). At 1p13, the LDL-associated SNP was also strongly correlated with CELSR2, PSRC1, and SORT1 transcript levels in human liver, and a proxy for this SNP was recently shown to affect risk for coronary artery disease. Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care. Blood concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular disease. Using genome-wide association data from three studies (n = 8,816 that included 2,758 individuals from the Diabetes Genetics Initiative specific to the current paper as well as 1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables reported in a companion paper in this issue) and targeted replication association analyses in up to 18,554 independent participants, we show that common SNPs at 18 loci are reproducibly associated with concentrations of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and/or triglycerides. Six of these loci are new (P < 5 x 10(-8) for each new locus). Of the six newly identified chromosomal regions, two were associated with LDL cholesterol (1p13 near CELSR2, PSRC1 and SORT1 and 19p13 near CILP2 and PBX4), one with HDL cholesterol (1q42 in GALNT2) and five with triglycerides (7q11 near TBL2 and MLXIPL, 8q24 near TRIB1, 1q42 in GALNT2, 19p13 near CILP2 and PBX4 and 1p31 near ANGPTL3). At 1p13, the LDL-associated SNP was also strongly correlated with CELSR2, PSRC1, and SORT1 transcript levels in human liver, and a proxy for this SNP was recently shown to affect risk for coronary artery disease. Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care. Blood concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular disease. Using genome-wide association data from three studies (n = 8,816 that included 2,758 individuals from the Diabetes Genetics Initiative specific to the current paper as well as 1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables reported in a companion paper in this issue) and targeted replication association analyses in up to 18,554 independent participants, we show that common SNPs at 18 loci are reproducibly associated with concentrations of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and/or triglycerides. Six of these loci are new (P < 5 10 super(-8) for each new locus). Of the six newly identified chromosomal regions, two were associated with LDL cholesterol (1p13 near CELSR2, PSRC1 and SORT1 and 19p13 near CILP2 and PBX4), one with HDL cholesterol (1q42 in GALNT2) and five with triglycerides (7q11 near TBL2 and MLXIPL, 8q24 near TRIB1, 1q42 in GALNT2, 19p13 near CILP2 and PBX4 and 1p31 near ANGPTL3). At 1p13, the LDL-associated SNP was also strongly correlated with CELSR2, PSRC1, and SORT1 transcript levels in human liver, and a proxy for this SNP was recently shown to affect risk for coronary artery disease. Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care. Blood concentrations of lipoproteins and lipids are heritable 1 risk factors for cardiovascular disease 2 , 3 . Using genome-wide association data from three studies ( n = 8,816 that included 2,758 individuals from the Diabetes Genetics Initiative specific to the current paper as well as 1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables reported in a companion paper in this issue 4 ) and targeted replication association analyses in up to 18,554 independent participants, we show that common SNPs at 18 loci are reproducibly associated with concentrations of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and/or triglycerides. Six of these loci are new ( P < 5 × 10 −8 for each new locus). Of the six newly identified chromosomal regions, two were associated with LDL cholesterol (1p13 near CELSR2 , PSRC1 and SORT1 and 19p13 near CILP2 and PBX4 ), one with HDL cholesterol (1q42 in GALNT2 ) and five with triglycerides (7q11 near TBL2 and MLXIPL , 8q24 near TRIB1 , 1q42 in GALNT2 , 19p13 near CILP2 and PBX4 and 1p31 near ANGPTL3 ). At 1p13, the LDL-associated SNP was also strongly correlated with CELSR2 , PSRC1 , and SORT1 transcript levels in human liver, and a proxy for this SNP was recently shown to affect risk for coronary artery disease 5 . Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care. Blood concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular disease. Using genome-wide association data from three studies (n = 8,816 that included 2,758 individuals from the Diabetes Genetics Initiative specific to the current paper as well as 1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables reported in a companion paper in this issue) and targeted replication association analyses in up to 18,554 independent participants, we show that common SNPs at 18 loci are reproducibly associated with concentrations of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and/or triglycerides. Six of these loci are new (P < 5 × 10 -8 for each new locus). Of the six newly identified chromosomal regions, two were associated with LDL cholesterol (1p13 near CELSR2, PSRC1 and SORT1 and 19p13 near CILP2 and PBX4), one with HDL cholesterol (1q42 in GALNT2) and five with triglycerides (7q11 near TBL2 and MLXIPL, 8q24 near TRIB1, 1q42 in GALNT2, 19p13 near CILP2 and PBX4 and 1p31 near ANGPTL3). At 1p13, the LDL-associated SNP was also strongly correlated with CELSR2, PSRC1, and SORT1 transcript levels in human liver, and a proxy for this SNP was recently shown to affect risk for coronary artery disease. Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care. [PUBLICATION ABSTRACT] |
| Audience | Academic |
| Author | Hedner, Thomas Hedblad, Bo Jousilahti, Pekka Orho-Melander, Marju Ordovas, Jose M Berglund, Göran Voight, Benjamin F Taskinen, Marja-Riitta Corella, Dolores Newton-Cheh, Christopher Cooper, Gregory M Salomaa, Veikko Melander, Olle Guiducci, Candace Roos, Charlotta Groop, Leif Altshuler, David M Surti, Aarti Burtt, Noël P Havulinna, Aki S Kathiresan, Sekar Vartiainen, Erkki Wahlstrand, Björn Tai, E Shyong Peltonen, Leena Rieder, Mark J |
| AuthorAffiliation | 2 Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA 9 National Public Health Institute Helsinki 00300, Finland 10 Department of Clinical Pharmacology, Sahlgrenska University Hospital, Göteborg 41345, Sweden 14 Department of Internal Medicine, University Hospital Malmö, Lund University, Malmö 20502, Sweden 4 Department of Clinical Sciences, Hypertension and Cardiovascular Diseases, University Hospital Malmö, Lund University, Malmö 20502, Sweden 1 Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA 5 Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA 16 Department of Medicine, University of Helsinki, Helsinki 00029, Finland 3 Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA 19 Department of Medicine, Helsinki University Hospital, Helsinki 00029, Finland 7 Center for Human Genetic Res |
| AuthorAffiliation_xml | – name: 6 Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Malmö, Lund University, Malmö 20502, Sweden – name: 8 Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA – name: 13 Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA – name: 15 Department of Epidemiological Research, University Hospital Malmö, Lund University, Malmö 20502, Sweden – name: 10 Department of Clinical Pharmacology, Sahlgrenska University Hospital, Göteborg 41345, Sweden – name: 11 Department of Preventive Medicine, School of Medicine, University of Valencia and CIBER Fisiopatología de la Obesidad y Nutrition, ISC III, Valencia 46010, Spain – name: 1 Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA – name: 5 Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA – name: 7 Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA – name: 14 Department of Internal Medicine, University Hospital Malmö, Lund University, Malmö 20502, Sweden – name: 12 Department of Endocrinology, Singapore General Hospital, 169608 Singapore – name: 4 Department of Clinical Sciences, Hypertension and Cardiovascular Diseases, University Hospital Malmö, Lund University, Malmö 20502, Sweden – name: 17 Department of Medical Genetics, University of Helsinki, Helsinki 00029, Finland – name: 9 National Public Health Institute Helsinki 00300, Finland – name: 19 Department of Medicine, Helsinki University Hospital, Helsinki 00029, Finland – name: 2 Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA – name: 18 Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK – name: 3 Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA – name: 16 Department of Medicine, University of Helsinki, Helsinki 00029, Finland – name: 20 Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA |
| Author_xml | – sequence: 1 givenname: Sekar surname: Kathiresan fullname: Kathiresan, Sekar email: skathiresan@partners.org organization: Cardiology Division, Massachusetts General Hospital, Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Department of Medicine, Harvard Medical School – sequence: 2 givenname: Olle surname: Melander fullname: Melander, Olle organization: Department of Clinical Sciences, Hypertension and Cardiovascular Diseases, University Hospital Malmö, Lund University – sequence: 3 givenname: Candace surname: Guiducci fullname: Guiducci, Candace organization: Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University – sequence: 4 givenname: Aarti surname: Surti fullname: Surti, Aarti organization: Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University – sequence: 5 givenname: Noël P surname: Burtt fullname: Burtt, Noël P organization: Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University – sequence: 6 givenname: Mark J surname: Rieder fullname: Rieder, Mark J organization: Department of Genome Sciences, University of Washington – sequence: 7 givenname: Gregory M surname: Cooper fullname: Cooper, Gregory M organization: Department of Genome Sciences, University of Washington – sequence: 8 givenname: Charlotta surname: Roos fullname: Roos, Charlotta organization: Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Malmö, Lund University – sequence: 9 givenname: Benjamin F surname: Voight fullname: Voight, Benjamin F organization: Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Center for Human Genetic Research, Massachusetts General Hospital, Department of Molecular Biology, Massachusetts General Hospital – sequence: 10 givenname: Aki S surname: Havulinna fullname: Havulinna, Aki S organization: National Public Health Institute – sequence: 11 givenname: Björn surname: Wahlstrand fullname: Wahlstrand, Björn organization: Department of Clinical Pharmacology, Sahlgrenska University Hospital – sequence: 12 givenname: Thomas surname: Hedner fullname: Hedner, Thomas organization: Department of Clinical Pharmacology, Sahlgrenska University Hospital – sequence: 13 givenname: Dolores surname: Corella fullname: Corella, Dolores organization: Department of Preventive Medicine, School of Medicine, University of Valencia and CIBER Fisiopatología de la Obesidad y Nutrition – sequence: 14 givenname: E Shyong surname: Tai fullname: Tai, E Shyong organization: Department of Endocrinology, Singapore General Hospital – sequence: 15 givenname: Jose M surname: Ordovas fullname: Ordovas, Jose M organization: Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Nutrition and Genomics Laboratory – sequence: 16 givenname: Göran surname: Berglund fullname: Berglund, Göran organization: Department of Internal Medicine, University Hospital Malmö, Lund University – sequence: 17 givenname: Erkki surname: Vartiainen fullname: Vartiainen, Erkki organization: National Public Health Institute – sequence: 18 givenname: Pekka surname: Jousilahti fullname: Jousilahti, Pekka organization: National Public Health Institute – sequence: 19 givenname: Bo surname: Hedblad fullname: Hedblad, Bo organization: Department of Epidemiological Research, University Hospital Malmö, Lund University – sequence: 20 givenname: Marja-Riitta surname: Taskinen fullname: Taskinen, Marja-Riitta organization: Department of Medicine, University of Helsinki – sequence: 21 givenname: Christopher surname: Newton-Cheh fullname: Newton-Cheh, Christopher organization: Cardiology Division, Massachusetts General Hospital, Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Department of Medicine, Harvard Medical School – sequence: 22 givenname: Veikko surname: Salomaa fullname: Salomaa, Veikko organization: National Public Health Institute – sequence: 23 givenname: Leena surname: Peltonen fullname: Peltonen, Leena organization: Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, National Public Health Institute, Department of Medical Genetics, University of Helsinki, Wellcome Trust Sanger Institute – sequence: 24 givenname: Leif surname: Groop fullname: Groop, Leif organization: Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Malmö, Lund University, Department of Medicine, Helsinki University Hospital – sequence: 25 givenname: David M surname: Altshuler fullname: Altshuler, David M organization: Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Department of Medicine, Harvard Medical School, Center for Human Genetic Research, Massachusetts General Hospital, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School – sequence: 26 givenname: Marju surname: Orho-Melander fullname: Orho-Melander, Marju email: marju.orho-melander@med.lu.se organization: Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Malmö, Lund University |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20066033$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/18193044$$D View this record in MEDLINE/PubMed https://gup.ub.gu.se/publication/70014$$DView record from Swedish Publication Index https://lup.lub.lu.se/record/1143930$$DView record from Swedish Publication Index oai:portal.research.lu.se:publications/9a463ad0-cb87-4718-a0e8-320856369f69$$DView record from Swedish Publication Index |
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| CODEN | NGENEC |
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| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 AUTHOR CONTRIBUTIONS S.K., O.M. and M.O.-M. designed the study. C.G. and A.S. performed genotyping and laboratory work. N.P.B. and M.O.-M. supervised the laboratory work. L.G., N.P.B. and D.M.A. designed and conducted the DGI genome-wide association study. M.-R.T. conducted the lipoprotein and lipid phenotype measurements in the DGI samples. G.B., B.H., and O.M. collected and phenotyped the Malmo Diet and Cancer Study sample. A.S.H., E.V., P.J., V.S. and L.P. collected and phenotyped the FINRISK97 sample. B.W., T.H. and O.M. collected and phenotyped the NORDIL sample. E.S.T., D.C. and J.M.O. conducted the replication study in the Singaporean sample. M.J.R. and G.M.C. conducted the liver expression studies. S.K., M.J.R., G.M.C., C.R., B.F.V. and M.O.-M. conducted the analyses. S.K. wrote the first draft of the paper. O.M., M.J.R., G.M.C., J.M.O., G.B., M.-R.T., C.N.-C., V.S., L.P., L.G., D.M.A. and M.O.-M. revised the manuscript for important intellectual content. |
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| Snippet | Blood concentrations of lipoproteins and lipids are heritable
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risk factors for cardiovascular disease
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,
3
. Using genome-wide association data from three... Blood concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular disease. Using genome-wide association data from three studies (n... Blood concentrations of lipoproteins and lipids are heritable super(1) risk factors for cardiovascular disease super(3). Using genome-wide association data... |
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| SubjectTerms | Aged Aging Agriculture Alleles Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Blood Blood lipoproteins Cancer Research Cardiac and Cardiovascular Systems Cardiology and Cardiovascular Disease Cardiovascular diseases Case-Control Studies Cholesterol Cholesterol, HDL - blood Cholesterol, HDL - genetics Cholesterol, LDL - blood Cholesterol, LDL - genetics Chromosomes Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 19 Chromosomes, Human, Pair 7 Chromosomes, Human, Pair 8 Clinical Medicine Cohort Studies Diagnosis DNA Female Fundamental and applied biological sciences. Psychology Gene Frequency Gene Function Gene loci Genetic aspects Genetic Markers Genetic Variation Genetics Genetics of eukaryotes. Biological and molecular evolution Genome Genome, Human HDL Health aspects Human Human Genetics Humans Kardiologi Kardiologi och kardiovaskulära sjukdomar Klinisk medicin LDL letter Linkage Disequilibrium Lipids Lipoproteins Liver Liver - metabolism Male Medical and Health Sciences Medicin och hälsovetenskap Messenger metabolism Middle Aged Pair 1 Pair 19 Pair 7 Pair 8 Physiological aspects Polymorphism Polymorphism, Single Nucleotide Probability Prospective Studies Proteolipids Randomized Controlled Trials as Topic Risk factors RNA RNA, Messenger - metabolism Sequence Analysis Sequence Analysis, DNA Single Nucleotide Single nucleotide polymorphisms Triglycerides Triglycerides - blood Triglycerides - genetics Type 2 diabetes Variation (Genetics) |
| Title | Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans |
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