Deazapurine Analogues Bearing a 1 H ‐Pyrazolo[3,4‐ b ]pyridin‐3(2 H )‐one Core: Synthesis and Biological Activity

A new methodology for the synthesis of fluorinated and non‐fluorinated 1 H ‐pyrazolo[3,4‐ b ]pyridin‐3‐ones was developed. The reactions proceed by cyclization of electron‐rich 3‐amino‐1 H ‐pyrazol‐5(4 H )‐ones with 1,3‐diketones and the products were obtained in good to excellent yields and with ex...

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Published inEuropean journal of organic chemistry Vol. 2018; no. 20-21; pp. 2629 - 2644
Main Authors Supe, Linda, Afzal, Saira, Mahmood, Abid, Ejaz, Syeda Abida, Hein, Martin, Iaroshenko, Viktor O., Villinger, Alexander, Lecka, Joanna, Sévigny, Jean, Iqbal, Jamshed, Langer, Peter
Format Journal Article
LanguageEnglish
Published 07.06.2018
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Summary:A new methodology for the synthesis of fluorinated and non‐fluorinated 1 H ‐pyrazolo[3,4‐ b ]pyridin‐3‐ones was developed. The reactions proceed by cyclization of electron‐rich 3‐amino‐1 H ‐pyrazol‐5(4 H )‐ones with 1,3‐diketones and the products were obtained in good to excellent yields and with excellent regioselectivity. The products, which can be regarded as deazapurine analogues, were tested for the alkaline phosphatase ( h ‐TNAP and h ‐IAP) and nucleotide pyrophosphatase/phosphodiesterase ( h ‐NPP1 and h ‐NPP3) inhibition profile. Most of the derivatives exhibited selective and potent inhibition on tissue non‐specific and intestinal alkaline phosphatase and nucleotide pyrophosphatase (NPP1 and NPP3) enzymes. Possible binding modes of the most potent inhibitors were studied by molecular docking analysis.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201800163