Proton Pump Inhibitor Use and Magnesium Concentrations in Hemodialysis Patients: A Cross-Sectional Study

• Published in: PloS one Vol. 10; no. 11; p. e0143656
• Main Authors: Nakashima, Akio, Ohkido, Ichiro, Yokoyama, Keitaro, Mafune, Aki, Urashima, Mitsuyoshi, Yokoo, Takashi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.11.2015; Public Library of Science (PLoS)
• Subjects: Acids; Aged; Analysis; Blood pressure; Calcification; Cardiac arrhythmia; Cross-sectional studies; Diabetes; Dialysis; Diuretics; Drug dosages; Epidemiology; Family medical history; Female; Health aspects; Hemodialysis; Histamine; Humans; Hypertension; Hypomagnesemia; Inhibitors; Internal medicine; Kidney diseases; Laboratories; Magnesium; Magnesium (Metal); Magnesium - blood; Magnesium Deficiency - blood; Magnesium Deficiency - epidemiology; Male; Medical research; Medicine; Metabolism; Middle Aged; Mortality; Multiple regression models; Nephrology; Patients; Potassium; Proton pump inhibitors; Proton Pump Inhibitors - adverse effects; Regression analysis; Regression models; Renal Dialysis - statistics & numerical data; Variance analysis; Japan

Magnesium concentration is a proven predictor of mortality in hemodialysis patients. Recent reports have indicated that proton pump inhibitor (PPI) use affects serum magnesium levels, however few studies have investigated the relationship between PPI use and magnesium levels in hemodialysis patients...