MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins

• Published in: Nature medicine Vol. 21; no. 12; pp. 1502 - 1507
• Main Authors: Tada, Takuya, Zhang, Yanzhao, Koyama, Takayoshi, Tobiume, Minoru, Tsunetsugu-Yokota, Yasuko, Yamaoka, Shoji, Fujita, Hideaki, Tokunaga, Kenzo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2015; Nature Publishing Group
• Subjects: 13/106; 14/19; 14/33; 38/1; 38/109; 38/22; 38/35; 38/39; 38/44; 38/70; 38/77; 38/89; 38/90; 631/326/596/1787; 631/326/596/2557; 82/29; 82/80; Antiviral agents; Apoptosis; Biomedicine; Cancer Research; Care and treatment; Cell Membrane - metabolism; Dendritic cells; Dosage and administration; Down-Regulation; env Gene Products, Human Immunodeficiency Virus - metabolism; Gene Silencing; Glycoproteins; Health aspects; HEK293 Cells; HIV; HIV (Viruses); HIV infection; HIV infections; HIV Infections - metabolism; HIV-1 - pathogenicity; HIV-1 - physiology; Human immunodeficiency virus 1; Humans; Infectious Diseases; Interleukins; Lentivirus; Lentivirus - metabolism; letter; Ligases; Macrophages; Macrophages - metabolism; Major histocompatibility complex; Membrane Glycoproteins - metabolism; Membrane proteins; Metabolic Diseases; Molecular Medicine; Neurosciences; Novels; Protein Binding; Protein Structure, Tertiary; Proteins; RNA, Messenger - genetics; RNA, Messenger - metabolism; Stomatitis; Testing; Transduction, Genetic; Transferrin; Tumor necrosis factor; Ubiquitin; Ubiquitin-Protein Ligases - chemistry; Ubiquitin-Protein Ligases - metabolism; Vesicular stomatitis virus; Viral Envelope Proteins - metabolism; Virion - metabolism; Japan

Kenzo Tokunaga and colleagues report that MARCH8 inhibits the incorporation of the HIV-1 envelope glycoprotein into virus particles, thereby reducing viral infectivity. Membrane-associated RING-CH 8 (MARCH8) is one of 11 members of the recently discovered MARCH family of RING (really interesting new...