Alterations of the benzodiazepine site of rat α6β2γ2‐GABA A receptor by replacement of several divergent amino‐terminal regions with the αl counterparts

• Published in: British journal of pharmacology Vol. 120; no. 4; pp. 559 - 564
• Main Authors: Im, Wha Bin, Pregenzer, Jeffrey F., Binder, Jay A., Alberts, Glen L., Im, Haesook K.
• Format: Journal Article
• Language: English
• Published: 10.02.2009

The benzodiazepine site of the α6β2γ2 subtype of γ‐aminobutyric acid A (GABA A ) receptors is distinguishable from that of the α1β2γ2 subtype by its inability to interact with classical benzodiazepines (i.e., diazepam) and its agonistic response to Ro 15–1788, which behaves as an antagonist in the α...