Structure of the TRPV1 ion channel determined by electron cryo-microscopy

• Published in: Nature (London) Vol. 504; no. 7478; pp. 107 - 112
• Main Authors: Liao, Maofu, Cao, Erhu, Julius, David, Cheng, Yifan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.12.2013; Nature Publishing Group
• Subjects: 101/28; 631/535/1258/1259; 631/92/269/1153; Animals; Ankyrin Repeat; Cryoelectron Microscopy; Crystal structure; Crystallization; HEK293 Cells; Humanities and Social Sciences; Humans; Ion channels; Membrane proteins; Microscopy; Models, Molecular; multidisciplinary; Observations; Physiological aspects; Protein Structure, Tertiary; Proteins; Rats; Science; Structure; TRPV Cation Channels - chemistry; United States; California

Transient receptor potential (TRP) channels are sensors for a wide range of cellular and environmental signals, but elucidating how these channels respond to physical and chemical stimuli has been hampered by a lack of detailed structural information. Here we exploit advances in electron cryo-micros...