Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitiv...

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Published in	Nature medicine Vol. 13; no. 11; pp. 1359 - 1362
Main Authors	Ray, Sandip, Britschgi, Markus, Herbert, Charles, Takeda-Uchimura, Yoshiko, Boxer, Adam, Blennow, Kaj, Friedman, Leah F, Galasko, Douglas R, Jutel, Marek, Karydas, Anna, Kaye, Jeffrey A, Leszek, Jerzy, Miller, Bruce L, Minthon, Lennart, Quinn, Joseph F, Rabinovici, Gil D, Robinson, William H, Sabbagh, Marwan N, So, Yuen T, Sparks, D Larry, Tabaton, Massimo, Tinklenberg, Jared, Yesavage, Jerome A, Tibshirani, Robert, Wyss-Coray, Tony
Format	Journal Article
Language	English
Published	New York Nature Publishing Group US 01.11.2007 Nature Publishing Group
Subjects	Alzheimer Disease - blood Alzheimer Disease - classification Alzheimer Disease - diagnosis Alzheimer's disease Biological analysis Biomarkers - blood Biomedical and Life Sciences Biomedicine Cancer Research Cell and Molecular Biology Cell- och molekylärbiologi Cellular biology Classification Clinical Medicine Cognition Disorders - blood Cognition Disorders - classification Cognition Disorders - diagnosis Cognitive ability disease gene-expression Humans immune Infectious Diseases Intercellular Signaling Peptides and Proteins - blood Klinisk medicin letter Medical and Health Sciences Medical diagnosis Medicin och hälsovetenskap Metabolic Diseases mild cognitive impairment Molecular Biology Molecular Medicine Molekylärbiologi Neurologi Neurology Neurosciences Phenotype Plasma Predictive Value of Tests Proteins responses Signal transduction
Online Access	Get full text
ISSN	1078-8956 1546-170X 1546-170X
DOI	10.1038/nm1653

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Abstract	A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2–6 years later. Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease.
AbstractList	A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2-6 years later. Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease. A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2-6 years later. Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease.A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2-6 years later. Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease.
Audience	Academic
Author	Tinklenberg, Jared Wyss-Coray, Tony Boxer, Adam Herbert, Charles Quinn, Joseph F Takeda-Uchimura, Yoshiko Sparks, D Larry Leszek, Jerzy Minthon, Lennart Ray, Sandip Karydas, Anna Jutel, Marek Miller, Bruce L Tabaton, Massimo Galasko, Douglas R Yesavage, Jerome A Kaye, Jeffrey A Sabbagh, Marwan N Friedman, Leah F Rabinovici, Gil D Robinson, William H Blennow, Kaj Tibshirani, Robert Britschgi, Markus So, Yuen T
Author_xml	– sequence: 1 givenname: Sandip surname: Ray fullname: Ray, Sandip organization: Satoris, Inc – sequence: 2 givenname: Markus surname: Britschgi fullname: Britschgi, Markus organization: Department of Neurology and Neurological Sciences, Stanford University School of Medicine – sequence: 3 givenname: Charles surname: Herbert fullname: Herbert, Charles organization: Satoris, Inc – sequence: 4 givenname: Yoshiko surname: Takeda-Uchimura fullname: Takeda-Uchimura, Yoshiko organization: Department of Neurology and Neurological Sciences, Stanford University School of Medicine – sequence: 5 givenname: Adam surname: Boxer fullname: Boxer, Adam organization: Department of Neurology, Memory and Aging Center – sequence: 6 givenname: Kaj surname: Blennow fullname: Blennow, Kaj organization: Department of Experimental Neuroscience, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, University of Göteborg, Blå stråket 15 – sequence: 7 givenname: Leah F surname: Friedman fullname: Friedman, Leah F organization: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine – sequence: 8 givenname: Douglas R surname: Galasko fullname: Galasko, Douglas R organization: Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive #9127 – sequence: 9 givenname: Marek surname: Jutel fullname: Jutel, Marek organization: Department of Internal Medicine and Allergology, Wroclaw Medical University – sequence: 10 givenname: Anna surname: Karydas fullname: Karydas, Anna organization: Department of Neurology, Memory and Aging Center – sequence: 11 givenname: Jeffrey A surname: Kaye fullname: Kaye, Jeffrey A organization: Layton Aging & Alzheimer's Disease Center, Oregon Health Sciences University, 3181 Southwest Sam Jackson Park Road, CR131 – sequence: 12 givenname: Jerzy surname: Leszek fullname: Leszek, Jerzy organization: Department of Psychiatry, Wroclaw Medical University – sequence: 13 givenname: Bruce L surname: Miller fullname: Miller, Bruce L organization: Department of Neurology, Memory and Aging Center – sequence: 14 givenname: Lennart surname: Minthon fullname: Minthon, Lennart organization: Department of Clinical Sciences Malmö, Clinical Memory Research Unit, Lund University, Universitetssjukhuset MAS, Ingång 56 plan 7 – sequence: 15 givenname: Joseph F surname: Quinn fullname: Quinn, Joseph F organization: Layton Aging & Alzheimer's Disease Center, Oregon Health Sciences University, 3181 Southwest Sam Jackson Park Road, CR131 – sequence: 16 givenname: Gil D surname: Rabinovici fullname: Rabinovici, Gil D organization: Department of Neurology, Memory and Aging Center – sequence: 17 givenname: William H surname: Robinson fullname: Robinson, William H organization: Division of Immunology and Rheumatology, Stanford University School of Medicine – sequence: 18 givenname: Marwan N surname: Sabbagh fullname: Sabbagh, Marwan N organization: Sun Health Research Institute, 10515 West Santa Fe Drive – sequence: 19 givenname: Yuen T surname: So fullname: So, Yuen T organization: Department of Neurology and Neurological Sciences, Stanford University School of Medicine – sequence: 20 givenname: D Larry surname: Sparks fullname: Sparks, D Larry organization: Sun Health Research Institute, 10515 West Santa Fe Drive – sequence: 21 givenname: Massimo surname: Tabaton fullname: Tabaton, Massimo organization: Department of Neurosciences, Ophthalmology, and Genetics, University of Genoa, Via A. De Toni 5 – sequence: 22 givenname: Jared surname: Tinklenberg fullname: Tinklenberg, Jared organization: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine – sequence: 23 givenname: Jerome A surname: Yesavage fullname: Yesavage, Jerome A organization: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine – sequence: 24 givenname: Robert surname: Tibshirani fullname: Tibshirani, Robert organization: Department of Health Research and Policy, Stanford University School of Medicine – sequence: 25 givenname: Tony surname: Wyss-Coray fullname: Wyss-Coray, Tony email: twc@stanford.edu organization: Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Geriatric Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/17934472$$D View this record in MEDLINE/PubMed https://gup.ub.gu.se/publication/80571$$DView record from Swedish Publication Index https://lup.lub.lu.se/record/971816$$DView record from Swedish Publication Index oai:portal.research.lu.se:publications/519597e4-e332-40b6-b2e4-518b85a56731$$DView record from Swedish Publication Index
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ContentType	Journal Article
Copyright	Springer Nature America, Inc. 2007 COPYRIGHT 2007 Nature Publishing Group Copyright Nature Publishing Group Nov 2007
Copyright_xml	– notice: Springer Nature America, Inc. 2007 – notice: COPYRIGHT 2007 Nature Publishing Group – notice: Copyright Nature Publishing Group Nov 2007
CorporateAuthor	Faculty of Medicine Clinical Memory Research Lunds universitet Klinisk minnesforskning Department of Clinical Sciences, Malmö Medicinska fakulteten Lund University Institutionen för kliniska vetenskaper, Malmö
CorporateAuthor_xml	– name: Faculty of Medicine – name: Medicinska fakulteten – name: Klinisk minnesforskning – name: Lund University – name: Institutionen för kliniska vetenskaper, Malmö – name: Clinical Memory Research – name: Lunds universitet – name: Department of Clinical Sciences, Malmö
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SubjectTerms	Alzheimer Disease - blood Alzheimer Disease - classification Alzheimer Disease - diagnosis Alzheimer's disease Biological analysis Biomarkers - blood Biomedical and Life Sciences Biomedicine Cancer Research Cell and Molecular Biology Cell- och molekylärbiologi Cellular biology Classification Clinical Medicine Cognition Disorders - blood Cognition Disorders - classification Cognition Disorders - diagnosis Cognitive ability disease gene-expression Humans immune Infectious Diseases Intercellular Signaling Peptides and Proteins - blood Klinisk medicin letter Medical and Health Sciences Medical diagnosis Medicin och hälsovetenskap Metabolic Diseases mild cognitive impairment Molecular Biology Molecular Medicine Molekylärbiologi Neurologi Neurology Neurosciences Phenotype Plasma Predictive Value of Tests Proteins responses Signal transduction
Title	Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
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