Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

• Published in: Nature Medicine Vol. 22; no. 2; pp. 138 - 145
• Main Authors: Wenger, Nikolaus, Moraud, Eduardo Martin, Gandar, Jerome, Musienko, Pavel, Capogrosso, Marco, Baud, Laetitia, Le Goff, Camille G, Barraud, Quentin, Pavlova, Natalia, Dominici, Nadia, Minev, Ivan R, Asboth, Leonie, Hirsch, Arthur, Duis, Simone, Kreider, Julie, Mortera, Andrea, Haverbeck, Oliver, Kraus, Silvio, Schmitz, Felix, DiGiovanna, Jack, van den Brand, Rubia, Bloch, Jocelyne, Detemple, Peter, Lacour, Stéphanie P, Bézard, Erwan, Micera, Silvestro, Courtine, Grégoire
• Format: Journal Article Magazine Article
• Language: English
• Published: New York Nature Publishing Group US 01.02.2016; Nature Publishing Group
• Subjects: 631/378/2632/1823; 692/617; Animal models; Animals; Biomechanical Phenomena; Biomedicine; Cancer Research; Care and treatment; Cellular biology; Computer Simulation; Electrodes; Evoked Potentials, Motor - physiology; Feedback, Sensory - physiology; Female; Hindlimb - innervation; Hindlimb - physiopathology; Infectious Diseases; Kinetics; Life Sciences; Locomotion - physiology; Medical treatment; Metabolic Diseases; Molecular Medicine; Motor ability; Motor Neurons - physiology; Muscle, Skeletal - innervation; Muscle, Skeletal - physiopathology; Neural stimulation; Neurons; Neurosciences; Physiological aspects; Physiology; Rats; Rats, Inbred Lew; Rodents; Spinal Cord - physiology; Spinal cord injuries; Spinal Cord Injuries - pathology; Spinal Cord Injuries - physiopathology; Spinal Cord Injuries - rehabilitation; Spinal Cord Stimulation; Spinal Nerve Roots - physiopathology; Time Factors; X-Ray Microtomography

Analysis of synergistic muscle activations during locomotion and anatomical tracing of muscle synergy representations in the rodent spinal cord guide the development of a new spinal implant for neuromodulation therapy. In multiple rodent models of spinal cord injury, spatiotemporal stimulation that...