Protocadherins mediate dendritic self-avoidance in the mammalian nervous system

• Published in: Nature (London) Vol. 488; no. 7412; pp. 517 - 521
• Main Authors: Lefebvre, Julie L., Kostadinov, Dimitar, Chen, Weisheng V., Maniatis, Tom, Sanes, Joshua R.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.08.2012; Nature Publishing Group
• Subjects: 631/378/1697; 631/378/2571; 631/80/79/1902; Adhesion; Amacrine Cells - cytology; Amacrine Cells - metabolism; Animals; Biological and medical sciences; Cadherins; Cadherins - genetics; Cadherins - metabolism; Cell Adhesion Molecules - genetics; Cell Adhesion Molecules - metabolism; Cells, Cultured; Cerebellum; Chromosome aberrations; Dendrites; Dendrites - metabolism; Dendritic cells; Drosophila; Drosophila melanogaster - genetics; Drosophila melanogaster - metabolism; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Evolution, Molecular; Eye and associated structures. Visual pathways and centers. Vision; Fundamental and applied biological sciences. Psychology; Humanities and Social Sciences; Insects; letter; Medical genetics; Medical sciences; Mice; Mice, Transgenic; Multiculturalism & pluralism; multidisciplinary; Nervous system; Physiological aspects; Protein Isoforms - genetics; Protein Isoforms - metabolism; Proteins; Purkinje Cells - cytology; Purkinje Cells - metabolism; Retina; Science; Vertebrates: nervous system and sense organs; United States; Cerebellum; Transmembrane protein; Molecular form; Amacrine neuron; Rodentia; Central nervous system; Purkinje neuron; Retina; Nervous system; Down syndrome; Cadherin; Adhesion; Encephalon; Dendrite; Eye; Visual system; Vertebrata; Discrimination; Mammalia; Mouse; Animal; Avoidance

Protocadherins are found to potentially provide the molecular diversity and complexity required to promote dendritic self-avoidance in mouse retina and cerebellum. Dendrite self-avoidance in mammalian neurons The complex geometry of neurons helps to determine the patterns of connectivity that underl...