Therapeutic efficacy of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant and macrolide-sensitive Mycoplasma pneumoniae pneumonia in pediatric patients

• Published in: PloS one Vol. 12; no. 3; p. e0173635
• Main Authors: Ishiguro, Nobuhisa, Koseki, Naoko, Kaiho, Miki, Ariga, Tadashi, Kikuta, Hideaki, Togashi, Takehiro, Oba, Koji, Morita, Keisuke, Nagano, Naoko, Nakanishi, Masanori, Hara, Kazuya, Hazama, Kyosuke, Watanabe, Toru, Yamanaka, Tatsuru, Sasaki, Satoshi, Furuyama, Hideto, Shibata, Mutsuo, Shida, Satoru, Ishizaka, Akihito, Tabata, Yuichi, Aoyagi, Hayato, Naito, Hiroyuki, Yoshioka, Mikio, Horino, Atsuko, Kenri, Tsuyoshi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.03.2017; Public Library of Science (PLoS)
• Subjects: Adolescent; Analysis; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibiotics; Antimicrobial agents; Azithromycin; Azithromycin - therapeutic use; Bacteriology; Biology and Life Sciences; Chemotherapy; Child; Children; Clarithromycin; Clarithromycin - therapeutic use; Dosage and administration; Drug Resistance, Bacterial - drug effects; Drug therapy; Female; Fever; Fluoroquinolones - therapeutic use; Health aspects; Hospitals; Humans; Infections; Infectious diseases; Informed consent; Male; Medicine; Medicine and Health Sciences; Microbial Sensitivity Tests; Minocycline; Minocycline - therapeutic use; Mycoplasma pneumonia; Mycoplasma pneumoniae; Mycoplasma pneumoniae - drug effects; Mycoplasma pneumoniae - genetics; Naphthyridines - therapeutic use; Observational studies; Patients; Pediatrics; Physical Sciences; Pneumonia; Pneumonia, Mycoplasma - drug therapy; Pneumonia, Mycoplasma - etiology; Tosufloxacin; Treatment Outcome; University graduates

To clarify therapeutic effects of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant Mycoplasma pneumoniae (MRMP) pneumonia and against macrolide-sensitive Mycoplasma pneumoniae (MSMP) pneumonia in pediatric patients. A prospective, multicenter observational study...