EPCO-44. SPATIAL TRANSCRIPTOMICS ENABLES STATISTICAL MODELING OF SEX DIFFERENCE IN GENE CO-EXPRESSION NETWORK AND IMMUNE LANDSCAPE OF GLIOBLASTOMA

• Published in: Neuro-oncology (Charlottesville, Va.) Vol. 26; no. Supplement_8; pp. viii11 - viii12
• Main Authors: Hao, Yue, Baker, Angela, Reid, George, Luo, Jingqin, Hilbush, Brian, Otero, Marcos, Streck, Christopher, Fink, Karen L, Snipes, George J, Mickey, Bruce E, Sloan, Andrew E, Barnholtz-Sloan, Jill S, Berens, Michael E
• Format: Journal Article
• Language: English
• Published: 11.11.2024

Glioblastoma (GBM) is characterized by inter- and intra-tumor molecular heterogeneity and demonstrated cell plasticity. Sex differences have been observed in various aspects: a male:female GBM incidence ratio is 1.6:1; standard of care treatments (debulking, radiation, and temozolomide) benefit fema...