The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

• Published in: Nature genetics Vol. 48; no. 10; pp. 1171 - 1184
• Main Authors: Chasman, Daniel I, Jackson, Anne U, Johnson, Toby, Thorleifsson, Gudmar, Luan, Jian'an, Pihur, Vasyl, Meirelles, Osorio, Bouatia-Naji, Nabila, Shah, Sonia, Nolte, Ilja M, Magnusson, Patrik K, Folkersen, Lasse, Kim, Young Jin, Zhao, Wei, Bochud, Murielle, Baldassarre, Damiano, Barroso, Inês, Chang, I-Shou, Chines, Peter S, Connell, John M, Döring, Angela, Dominiczak, Anna F, Doney, Alex S F, Erdmann, Jeanette, Eriksson, Per, Evangelou, Evangelos, Evans, Alun, Felix, Janine F, Gertow, Karl, Goodarzi, Mark O, Gorski, Mathias, Groves, Christopher J, Gyllensten, Ulf, Hallmans, Göran, Hercberg, Serge, Hicks, Andrew A, Hsiung, Chao A, Kang, Hyun Min, Kathiresan, Sekar, Khaw, Kay-Tee, Kim, Yun Kyoung, Klopp, Norman, Kolovou, Genovefa, Kooner, Jaspal S, Kosova, Gulum, Kutalik, Zoltan, Lee, I-Te, Lee, Wen-Jane, Lindström, Jaana, Lobbens, Stéphane, Männistö, Satu, Mach, François, Marouli, Eirini, McKenzie, Colin A, Menni, Cristina, Morris, Andrew D, Nagaraja, Ramaiah, Nikus, Kjell, O'Reilly, Paul F, Ong, Ken K, Parsa, Afshin, Penninx, Brenda W, Rossouw, Jacques, Saramies, Jouko, Shin, Young-Ah, Stanton, Alice V, Sundstrom, Johan, Syvänen, Ann-Christine, Tarasov, Kirill V, Thorsteinsdottir, Unnur, Uitterlinden, Andre G, Vaez, Ahmad, van Iperen, Erik P A, Vasan, Ramachandran S, Verwoert, Germaine C, Wain, Louise V, Watkins, Hugh, Westra, Harm-Jan, Wilks, Rainford, Wilsgaard, Tom, Yang, Tsun-Po, Yengo, Loic, Bovet, Pascal, Cooper, Richard S, Elliott, Paul, Willer, Cristen J, Lind, Lars, Assimes, Themistocles L, Snieder, Harold, Melander, Olle, Laakso, Markku, Rauramaa, Rainer, Ingelsson, Erik, Hveem, Kristian, Kumari, Meena, Rotter, Jerome I, Lakatta, Edward G, Palmer, Colin N A, Chakravarti, Aravinda, Deloukas, Panos
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.10.2016; Nature Publishing Group
• Subjects: 45/43; 631/208/205/2138; 692/699/75/243; Agriculture; Analysis; Animal Genetics and Genomics; Asian People - genetics; Basic Medicine; Biomedicine; Black People - genetics; Blood pressure; Blood Pressure - genetics; Blood pressure regulation; Cancer Research; Cells, Cultured; Consortia; Gene Function; Genealogy; Genetic aspects; Genetics; Genome-Wide Association Study; Genomes; Genomics; Genotypes; Human Genetics; Humans; Hypertension - genetics; Hypertension - pathology; Hypotheses; Kardiologi; Klinisk medicin; Life Sciences; Medical and Health Sciences; Medical Genetics; Medical schools; Medicin och hälsovetenskap; Medicinsk genetik; Medicinska och farmaceutiska grundvetenskaper; Meta-analysis; Microarray Analysis; Polymorphism, Single Nucleotide; Studies

Patricia Munroe, Christopher Newton-Cheh, Andrew Morris and colleagues perform association studies in over 340,000 individuals of European ancestry and identify 66 loci, of which 17 are novel, involved in blood pressure regulation. The risk SNPs are enriched for cis -regulatory elements, particularl...