Validation of a genetic risk score for atrial fibrillation: A prospective multicenter cohort study

• Published in: PLoS medicine Vol. 15; no. 3; p. e1002525
• Main Authors: Muse, Evan D, Wineinger, Nathan E, Spencer, Emily G, Peters, Melissa, Henderson, Riley, Zhang, Yunyue, Barrett, Paddy M, Rivera, Steven P, Wohlgemuth, Jay G, Devlin, James J, Shiffman, Dov, Topol, Eric J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.03.2018; Public Library of Science (PLoS)
• Subjects: Adhesion tests; Aged; Aminopeptidases - genetics; Analysis; Arrhythmia; Atrial fibrillation; Atrial Fibrillation - complications; Atrial Fibrillation - diagnosis; Atrial Fibrillation - genetics; Body mass; Cardiovascular disease; Caveolin 1 - genetics; Cerebral infarction; Cohort analysis; Cohort Studies; Diabetes mellitus; Diagnosis; Echocardiography; EKG; Electrocardiography; Electrocardiography, Ambulatory - methods; Female; Fibrillation; Genetic aspects; Genetic screening; Genetic Testing - methods; Health risk assessment; Health risks; Heart diseases; Homeobox Protein PITX2; Homeodomain Proteins - genetics; Humans; Male; Medicine and Health Sciences; Middle Aged; Morbidity; Myocardial infarction; Patients; Physical Sciences; Polymorphism, Single Nucleotide; Prospective Studies; Research and Analysis Methods; Risk assessment; Risk Assessment - methods; Risk Factors; Single-nucleotide polymorphism; Small-Conductance Calcium-Activated Potassium Channels - genetics; Smoking; Stroke - etiology; Stroke - prevention & control; Systematic review; Time Factors; Transcription Factors - genetics; La Jolla California; California; United States > US; San Juan Capistrano California

Atrial fibrillation (AF) is the most commonly encountered arrhythmia and is associated with an elevated risk of stroke. Improving the identification of patients with the highest risk for AF to enable appropriate surveillance and treatment, if necessary, is critical to reducing AF-associated morbidit...