DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans

• Published in: PLoS genetics Vol. 12; no. 7; p. e1006133
• Main Authors: Munkácsy, Erin, Khan, Maruf H, Lane, Rebecca K, Borror, Megan B, Park, Jae H, Bokov, Alex F, Fisher, Alfred L, Link, Christopher D, Rea, Shane L
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.07.2016; Public Library of Science (PLoS)
• Subjects: Alzheimer's disease; Alzheimers disease; Animals; Bioenergetics; Biology and Life Sciences; Biosynthesis; Caenorhabditis elegans; Caenorhabditis elegans - physiology; Caenorhabditis elegans Proteins - physiology; DNA sequencing; Electron Transport; Electron Transport Chain Complex Proteins - physiology; Funding; Gene expression; Gene Expression Regulation; Genes, Reporter; Genetic aspects; Green Fluorescent Proteins - metabolism; MAP Kinase Kinase Kinases - physiology; Medicine and Health Sciences; Methods; Mitochondria; Mitochondria - metabolism; Mitochondrial DNA; Mitogen-Activated Protein Kinases - physiology; Mutation; Nematoda; Nematodes; Oxidative stress; p38 Mitogen-Activated Protein Kinases - metabolism; Pathogens; Phosphotransferases; Physiological aspects; Proteins; Research and Analysis Methods; RNA Interference; Signal Transduction; Surveillance; Unfolded Protein Response; Worms

Mitochondrial dysfunction underlies numerous age-related pathologies. In an effort to uncover how the detrimental effects of mitochondrial dysfunction might be alleviated, we examined how the nematode C. elegans not only adapts to disruption of the mitochondrial electron transport chain, but in many...