Negative autoregulation by FAS mediates robust fetal erythropoiesis

• Published in: PLoS biology Vol. 5; no. 10; p. e252
• Main Authors: Socolovsky, Merav, Murrell, Michael, Liu, Ying, Pop, Ramona, Porpiglia, Ermelinda, Levchenko, Andre
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.10.2007; Public Library of Science (PLoS)
• Subjects: Algorithms; Animals; Apoptosis; Apoptosis - physiology; Cell Differentiation; Cell Separation; Cloning; Computational Biology; Developmental Biology; Effect of alcohol on; Embryos; Erythrocytes - cytology; Erythrocytes - metabolism; Erythroid Precursor Cells - cytology; Erythroid Precursor Cells - metabolism; Erythropoiesis - physiology; Fas Ligand Protein - metabolism; fas Receptor - metabolism; Feedback, Physiological; Fetal alcohol syndrome; Fetus; Fetus - embryology; Fetus - metabolism; Flow Cytometry; Gene expression; Hematology; Homeostasis - physiology; Ligands; Liver; Liver - embryology; Liver - metabolism; Mathematics; Mice; Mice, Inbred C57BL; None; Ordinary differential equations; Signal Transduction; United States; Erythropoiesis; Signal Transduction; Cell Separation; Liver; Mice, Inbred C57BL; Erythrocytes; Homeostasis; Antigens, CD95; Fas Ligand Protein; Feedback, Physiological; Algorithms; Animals; Flow Cytometry; Erythroid Precursor Cells; Fetus; Cell Differentiation; Mice; Apoptosis

Tissue development is regulated by signaling networks that control developmental rate and determine ultimate tissue mass. Here we present a novel computational algorithm used to identify regulatory feedback and feedforward interactions between progenitors in developing erythroid tissue. The algorith...