Integrated analysis of copy number variation and genome-wide expression profiling in colorectal cancer tissues

• Published in: PloS one Vol. 9; no. 4; p. e92553
• Main Authors: Ali Hassan, Nur Zarina, Mokhtar, Norfilza Mohd, Kok Sin, Teow, Mohamed Rose, Isa, Sagap, Ismail, Harun, Roslan, Jamal, Rahman
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2014; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Biology and Life Sciences; Cancer; Care and treatment; Cell cycle; Cell division; Chromosome 20; Chromosome 8; Chromosomes; Chromosomes, Human, Pair 20 - genetics; Chromosomes, Human, Pair 8 - genetics; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Complications and side effects; Copy number; Datasets; Deoxyribonucleic acid; DNA; Epithelium; Female; Gene Dosage; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes; Genes, Neoplasm; Genetic aspects; Genetic testing; Genome-Wide Association Study; Genomes; Humans; Kinases; Male; Medical prognosis; Medical research; Medicine; Medicine and Health Sciences; Middle Aged; Molecular biology; Multiplexing; Pathology; Patient outcomes; Patients; Phosphatase; Radiation therapy; Research and Analysis Methods; Risk factors; Studies; Surgery; Tissues; Malaysia; Kuala Lumpur Malaysia

Integrative analyses of multiple genomic datasets for selected samples can provide better insight into the overall data and can enhance our knowledge of cancer. The objective of this study was to elucidate the association between copy number variation (CNV) and gene expression in colorectal cancer (...