Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons - Gielen, Vera; Sykes, Annemarie; Zhu, Jie; Chan, Brian; Macintyre, Jonathan; Regamey, Nicolas; Kieninger, Elisabeth; Gupta, Atul; Shoemark, Amelia; Bossley, Cara; Davies, Jane; Saglani, Sejal; et al. (Journal of allergy and clinical immunology, 2015)
Keywords: Adolescent; Adult; Allergy and Immunology; Animals; Asthma; Asthma - complications; Asthma - immunology; Asthma - virology; asthma exacerbation; atopy; Cell Nucleus - metabolism; Cells, Cultured; Child; Child, Preschool; cytokine; Cytokines; Enterovirus; Families & family life; Female; Gene expression; Human subjects; Humans; Immunity, Innate - genetics; Infections; innate immunity; interferon; Interferon-gamma - genetics; Interferon-gamma - metabolism; Investigations; Kinases; Male; Mechanisms of Allergy and Clinical Immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Molecular weight; Mortality; Mutation - genetics; Picornaviridae; Picornaviridae Infections - complications; Picornaviridae Infections - immunology; Picornaviridae Infections - virology; Protein expression; Protein Transport; Proteins; Respiratory Mucosa - immunology; Respiratory Mucosa - virology; Rhinovirus; Rhinovirus - physiology; Rodents; suppressor of cytokine signaling; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling Proteins - genetics; Suppressor of Cytokine Signaling Proteins - metabolism; TH2 inflammation; Up-Regulation - genetics; Viral infections; Virus Replication; Young Adult; NANA; SOCS1wt; polyI:C; TH2 inflammation; GFP; NF-κB; innate immunity; NLS; KC; asthma exacerbation; ISG; Rhinovirus; cytokine; AA; suppressor of cytokine signaling; BEC; CISH; atopy; asthma; SOCS; interferon; BAL; STAT; STRA; LIX; ISRE; Atopic asthma; Interferon-stimulated gene; Signal transducer and activator of transcription; LPS-induced CXC chemokine; Nuclear localization sequence; Bronchoalveolar lavage; Cytokine-inducible SH2-containing protein; Polyinosinic-polycytidylic acid; Bronchial epithelial cell; Full-length wild-type human SOCS1; Severe therapy-resistant atopic asthma; Nuclear factor κB; T H2 inflammation; Nonatopic nonasthmatic