Multiple Mechanisms Promote the Retained Expression of Gene Duplicates in the Tetraploid Frog Xenopus laevis

• Published in: PLoS genetics Vol. 2; no. 4; p. e56
• Main Authors: Chain, Frédéric J. J, Evans, Ben J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2006; Public Library of Science (PLoS)
• Subjects: Amino Acid Substitution; Animals; Codon - genetics; Eukaryotes; Evolution; Evolution, Molecular; Frogs; Gene Duplication; Gene Expression Regulation; Genetic aspects; Genetic Variation; Genetics; Genetics/Comparative Genomics; Genetics/Genomics; Genomes; Medical research; Models, Genetic; Molecular Sequence Data; Mutation; Polyploidy; Proteins; Time; Vertebrates; Xenopus; Xenopus laevis; Xenopus laevis - genetics

Gene duplication provides a window of opportunity for biological variants to persist under the protection of a co-expressed copy with similar or redundant function. Duplication catalyzes innovation (neofunctionalization), subfunction degeneration (subfunctionalization), and genetic buffering (redund...