The human plasma-metabolome: Reference values in 800 French healthy volunteers; impact of cholesterol, gender and age

• Published in: PloS one Vol. 12; no. 3; p. e0173615
• Main Authors: Trabado, Séverine, Al-Salameh, Abdallah, Croixmarie, Vincent, Masson, Perrine, Corruble, Emmanuelle, Fève, Bruno, Colle, Romain, Ripoll, Laurent, Walther, Bernard, Boursier-Neyret, Claire, Werner, Erwan, Becquemont, Laurent, Chanson, Philippe
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.03.2017; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Age; Age Factors; Aged; Aged, 80 and over; Aging; Amines; Amino acids; Atherosclerosis; Biogenic amines; Biological markers; Biology and Life Sciences; Biomarkers; Biomarkers - blood; Blood; Blood plasma; Chain branching; Cholesterol; Cholesterol - metabolism; Creatinine; Cross-Sectional Studies; Demographic aspects; Drugs; Family medical history; Female; France; Gender; Geriatrics; Health aspects; Healthy Volunteers; Hexose; Humans; Insulin-like growth factors; Laboratory tests; Life Sciences; Lipids; Male; Mass spectrometry; Mass spectroscopy; Medical research volunteers; Medicine and Health Sciences; Metabolism; Metabolites; Metabolome; Metabolomics; Metabolomics - methods; Middle Aged; Nutrition research; Older people; Oxidative stress; Plasma; Plasma levels; Population; Principal Component Analysis; Principal components analysis; Reference Values; Sex Characteristics; Studies; Variability; Young Adult; France

Metabolomic approaches are increasingly used to identify new disease biomarkers, yet normal values of many plasma metabolites remain poorly defined. The aim of this study was to define the "normal" metabolome in healthy volunteers. We included 800 French volunteers aged between 18 and 86,...