APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

• Published in: Molecular neurodegeneration Vol. 17; no. 1; pp. 62 - 47
• Main Authors: Fernández-Calle, Rosalía, Konings, Sabine C., Frontiñán-Rubio, Javier, García-Revilla, Juan, Camprubí-Ferrer, Lluís, Svensson, Martina, Martinson, Isak, Boza-Serrano, Antonio, Venero, José Luís, Nielsen, Henrietta M., Gouras, Gunnar K., Deierborg, Tomas
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.09.2022; BioMed Central; BMC
• Subjects: Advertising executives; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Amyotrophic lateral sclerosis; Apolipoprotein E; Apolipoprotein E2 - genetics; Apolipoprotein E3 - genetics; Apolipoprotein E4; Apolipoprotein E4 - genetics; Apolipoproteins; Apolipoproteins E - metabolism; Autophagy; Brain; Cell interactions; Cholesterol; Chromosomes; Clinical Medicine; Clinical trials; Exercise; Gene expression; Genetic aspects; Genomes; Genotype; Genotype & phenotype; Health risk assessment; Humans; Hypotheses; Inflammation; Injuries; Klinisk medicin; Medical and Health Sciences; Medicin och hälsovetenskap; Metabolism; Movement disorders; Multiple sclerosis; Nervous system; Neurodegeneration; Neurodegenerative diseases; Neurodegenerative Diseases - genetics; Neurofibrillary tangles; Neuroinflammation; Neurologi; Neurology; Nucleotides; Parkinson's disease; Pathology; Peptides; Physiology; Plaque, Amyloid - pathology; Proteins; Review; Reviews; Risk factors; Senile plaques; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Structure-function relationships; Tau protein; tau Proteins - genetics; Traumatic brain injury; β-Amyloid; Neuroinflammation; Alzheimer’s disease; Apolipoprotein E; Neurodegeneration

ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of the most influential risk factors for the development of late-onset Alzheimer's disease (AD). Neuroinflammation has becom...