基于椎管内微刺激的大鼠后肢运动脊髓功能核心区域测定
为了提高基于脊髓功能性电激励重建后肢运动功能时电极植入位置的准确性和可靠性,实验测定了大鼠后肢运动相关的脊髓功能核心区域的分布情况。此次研究利用三维扫描式椎管内微刺激技术对脊髓进行刺激,以产生髋关节、膝关节和踝关节等后肢运动,并记录诱发这些运动的脊髓内坐标。为了克服个体间差异,本文对12只SD大鼠的脊髓功能区域归一化后进行叠加,得到踝关节背屈、屈髋关节、伸髋关节和内收髋关节等运动的脊髓功能核心区域。本研究为微电子神经桥接系统用于后肢运动功能的重建提供了参考。...
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| Published in | Sheng wu yi xue gong cheng xue za zhi Vol. 34; no. 4; pp. 622 - 626 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese English |
| Published |
中国四川
四川大学华西医院
01.08.2017
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| Subjects | |
| Online Access | Get full text |
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| Summary: | 为了提高基于脊髓功能性电激励重建后肢运动功能时电极植入位置的准确性和可靠性,实验测定了大鼠后肢运动相关的脊髓功能核心区域的分布情况。此次研究利用三维扫描式椎管内微刺激技术对脊髓进行刺激,以产生髋关节、膝关节和踝关节等后肢运动,并记录诱发这些运动的脊髓内坐标。为了克服个体间差异,本文对12只SD大鼠的脊髓功能区域归一化后进行叠加,得到踝关节背屈、屈髋关节、伸髋关节和内收髋关节等运动的脊髓功能核心区域。本研究为微电子神经桥接系统用于后肢运动功能的重建提供了参考。 |
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| Bibliography: | intraspinal microstimulation; motor function; functional electrical stimulation; core region In order to improve the accuracy and reliability of the electrodes implant location when using spinal functional electrical stimulation to rebuild hindlimb motor function, we measured the distributions of function core regions in rat spinal cord associated with hindlimb movements. In this study, we utilized three-dimensional scanning intraspinal microstimulation technology to stimulate the rat spinal cord to generate hip, knee and ankle joint movements, and acquired the coordinates of the sites in spinal cord which evoked these movements. In this article, 12 SD rats were used to overcome the individual differences in the functional region of the spinal cord. After normalized and overlaid the messages, we obtained the function core regions in spinal cord associated with ankle dorsiflexion movement, hip flexion movement, hip extension movement and hip adduction movement. It provides a reference for rebuilding the hindlim |
| ISSN: | 1001-5515 |
| DOI: | 10.7507/1001-5515.201607029 |