Ciliary Neurotrophic Factor Protects Striatal Neurons against Excitotoxicity by Enhancing Glial Glutamate Uptake

• Published in: PloS one Vol. 5; no. 1; p. e8550
• Main Authors: Beurrier, Corinne, Faideau, Mathilde, Bennouar, Khaled-Ezaheir, Escartin, Carole, Kerkerian-Le Goff, Lydia, Bonvento, Gilles, Gubellini, Paolo
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2010; Public Library of Science (PLoS)
• Subjects: Alzheimer's disease; Amino Acid Transport System X-AG; Amino Acid Transport System X-AG - antagonists & inhibitors; Amino acids; Animal models; Animals; Aspartic Acid; Aspartic Acid - pharmacology; Brain research; Cell Biology/Cellular Death and Stress Responses; Ciliary Neurotrophic Factor; Ciliary Neurotrophic Factor - physiology; Cocaine; Comparative analysis; Corpus Striatum; Corpus Striatum - cytology; Corpus Striatum - drug effects; Corpus Striatum - metabolism; Cortex; Cytokines; Data processing; Dopamine; Enzymes; Evoked Potentials; Evoked Potentials - drug effects; Evoked Potentials - physiology; Excitation; Excitotoxicity; Glutamate; Glutamate receptors; Glutamatergic transmission; Glutamic Acid; Glutamic Acid - metabolism; Glutamic acid receptors; Huntingtons disease; In Vitro Techniques; Life Sciences; Localization; Medical treatment; Neostriatum; Nervous system diseases; Neurobiology; Neurodegeneration; Neurodegenerative diseases; Neurological diseases; Neurological Disorders/Movement Disorders; Neuronal-glial interactions; Neurons; Neurons - drug effects; Neurons - metabolism; Neurons and Cognition; Neuroprotection; Neuroscience; Neuroscience/Neural Homeostasis; Neuroscience/Neuronal and Glial Cell Biology; Neuroscience/Neuronal Signaling Mechanisms; Neurotoxicity; Overflow; Pathology/Neuropathology; Quinolinic Acid; Quinolinic Acid - pharmacology; Rats; Recovery; Rodents; Spiny neurons; Trends; France; Glutamic Acid; Amino Acid; Animals; Corpus Striatum; Rats; Ciliary Neurotrophic factor; Aspartic Acid; Quinolinic Acid

Ciliary neurotrophic factor (CNTF) is a potent neuroprotective cytokine in different animal models of glutamate-induced excitotoxicity, although its action mechanisms are still poorly characterized. We tested the hypothesis that an increased function of glial glutamate transporters (GTs) could under...