A key role for orexin in panic anxiety
Orexin, a neuropeptide best known for its role in arousal and its absence in people with narcolepsy, is also involved in the pathophysiology of panic anxiety disorder. Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In individuals with panic disorder there is...
Saved in:
| Published in | Nature medicine Vol. 16; no. 1; pp. 111 - 115 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.01.2010
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Orexin, a neuropeptide best known for its role in arousal and its absence in people with narcolepsy, is also involved in the pathophysiology of panic anxiety disorder.
Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In individuals with panic disorder there is evidence of decreased central γ-aminobutyric acid (GABA) activity as well as marked increases in autonomic and respiratory responses after intravenous infusions of hypertonic sodium lactate
1
,
2
,
3
. In a rat model of panic disorder, chronic inhibition of GABA synthesis in the dorsomedial-perifornical hypothalamus of rats produces anxiety-like states and a similar vulnerability to sodium lactate–induced cardioexcitatory responses
4
,
5
,
6
,
7
,
8
,
9
. The dorsomedial-perifornical hypothalamus is enriched in neurons containing orexin (ORX, also known as hypocretin)
10
, which have a crucial role in arousal
10
,
11
, vigilance
10
and central autonomic mobilization
12
, all of which are key components of panic. Here we show that activation of ORX-synthesizing neurons is necessary for developing a panic-prone state in the rat panic model, and either silencing of the hypothalamic gene encoding ORX (
Hcrt
) with RNAi or systemic ORX-1 receptor antagonists blocks the panic responses. Moreover, we show that human subjects with panic anxiety have elevated levels of ORX in the cerebrospinal fluid compared to subjects without panic anxiety. Taken together, our results suggest that the ORX system may be involved in the pathophysiology of panic anxiety and that ORX antagonists constitute a potential new treatment strategy for panic disorder. |
|---|---|
| AbstractList | Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In individuals with panic disorder there is evidence of decreased central γ-aminobutyric acid (GABA) activity as well as marked increases in autonomic and respiratory responses after intravenous infusions of hypertonic sodium lactate (1-3). In a rat model of panic disorder, chronic inhibition of GABA synthesis in the dorsomedial-perifornical hypothalamus of rats produces anxiety-like states and a similar vulnerability to sodium lactate-induced card ioexcitatory responses (4-9). The dorsomedial-perifornical hypothalamus is enriched in neurons containing orexin (ORX, also known as hypocretin) (10), which have a crucial role in arousal (10,11), vigilance (10) and central autonomic mobilization (12), all of which are key components of panic. Here we show that activation of ORX-synthesizing neurons is necessary for developing a panic-prone state in the rat panic model, and either silencing of the hypothalamic gene encoding ORX (Hcrt) with RNAi or systemic ORX-1 receptor antagonists blocks the panic responses. Moreover, we show that human subjects with panic anxiety have elevated levels of ORX in the cerebrospinal fluid compared to subjects without panic anxiety. Taken together, our results suggest that the ORX system may be involved in the pathophysiology of panic anxiety and that ORX antagonists constitute a potential new treatment strategy for panic disorder. Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In individuals with panic disorder there is evidence of decreased central gamma-aminobutyric acid (GABA) activity as well as marked increases in autonomic and respiratory responses after intravenous infusions of hypertonic sodium lactate(1-3). In a rat model of panic disorder, chronic inhibition of GABA synthesis in the dorsomedial-perifornical hypothalamus of rats produces anxiety-like states and a similar vulnerability to sodium lactate-induced cardioexcitatory responses(4-9). The dorsomedial-perifornical hypothalamus is enriched in neurons containing orexin (ORX, also known as hypocretin)(10), which have a crucial role in arousal(10,11), vigilance(10) and central autonomic mobilization(12), all of which are key components of panic. Here we show that activation of ORX-synthesizing neurons is necessary for developing a panic-prone state in the rat panic model, and either silencing of the hypothalamic gene encoding ORX (Hcrt) with RNAi or systemic ORX-1 receptor antagonists blocks the panic responses. Moreover, we show that human subjects with panic anxiety have elevated levels of ORX in the cerebrospinal fluid compared to subjects without panic anxiety. Taken together, our results suggest that the ORX system may be involved in the pathophysiology of panic anxiety and that ORX antagonists constitute a potential new treatment strategy for panic disorder. (C) 2010 Nature America, Inc. All rights reserved. Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In individuals with panic disorder there is evidence of decreased central gamma-aminobutyric acid (GABA) activity as well as marked increases in autonomic and respiratory responses after intravenous infusions of hypertonic sodium lactate. In a rat model of panic disorder, chronic inhibition of GABA synthesis in the dorsomedial-perifornical hypothalamus of rats produces anxiety-like states and a similar vulnerability to sodium lactate-induced cardioexcitatory responses. The dorsomedial-perifornical hypothalamus is enriched in neurons containing orexin (ORX, also known as hypocretin), which have a crucial role in arousal, vigilance and central autonomic mobilization, all of which are key components of panic. Here we show that activation of ORX-synthesizing neurons is necessary for developing a panic-prone state in the rat panic model, and either silencing of the hypothalamic gene encoding ORX (Hcrt) with RNAi or systemic ORX-1 receptor antagonists blocks the panic responses. Moreover, we show that human subjects with panic anxiety have elevated levels of ORX in the cerebrospinal fluid compared to subjects without panic anxiety. Taken together, our results suggest that the ORX system may be involved in the pathophysiology of panic anxiety and that ORX antagonists constitute a potential new treatment strategy for panic disorder.Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In individuals with panic disorder there is evidence of decreased central gamma-aminobutyric acid (GABA) activity as well as marked increases in autonomic and respiratory responses after intravenous infusions of hypertonic sodium lactate. In a rat model of panic disorder, chronic inhibition of GABA synthesis in the dorsomedial-perifornical hypothalamus of rats produces anxiety-like states and a similar vulnerability to sodium lactate-induced cardioexcitatory responses. The dorsomedial-perifornical hypothalamus is enriched in neurons containing orexin (ORX, also known as hypocretin), which have a crucial role in arousal, vigilance and central autonomic mobilization, all of which are key components of panic. Here we show that activation of ORX-synthesizing neurons is necessary for developing a panic-prone state in the rat panic model, and either silencing of the hypothalamic gene encoding ORX (Hcrt) with RNAi or systemic ORX-1 receptor antagonists blocks the panic responses. Moreover, we show that human subjects with panic anxiety have elevated levels of ORX in the cerebrospinal fluid compared to subjects without panic anxiety. Taken together, our results suggest that the ORX system may be involved in the pathophysiology of panic anxiety and that ORX antagonists constitute a potential new treatment strategy for panic disorder. Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In subjects with panic disorder there is evidence of decreased central GABAergic activity as well as marked increases in autonomic and respiratory responses following intravenous infusions of 0.5M sodium lactate 1 – 3 . In an animal model of panic disorder, chronic inhibition of GABA synthesis in the dorsomedial/perifornical hypothalamus of rats produces anxiety-like states and a similar vulnerability to sodium lactate-induced cardioexcitatory responses 4 – 9 . The dorsomedial/perifornical hypothalamus is enriched in orexin (ORX, also known as hypocretin)-containing neurons 10 that play a critical role in arousal 10 , 11 , vigilance 10 and central autonomic mobilization 12 , all of which are key components of panic. Here, we demonstrate that activation of the ORX neurons is necessary for developing a panic-prone state in the animal model, and either silencing the hypothalamic ORX gene ( Hcrt ) product with RNA interference or systemic ORX1 antagonists blocks the panic responses. Moreover, we show that subjects with panic anxiety have elevated levels of ORX in the cerebrospinal fluid compared to subjects without panic anxiety. Taken together our results suggest that the ORX system may be involved in the pathophysiology of panic anxiety, and that ORX antagonists constitute a potential novel treatment strategy for panic disorder. Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In individuals with panic disorder there is evidence of decreased central gamma-aminobutyric acid (GABA) activity as well as marked increases in autonomic and respiratory responses after intravenous infusions of hypertonic sodium lactate. In a rat model of panic disorder, chronic inhibition of GABA synthesis in the dorsomedial-perifornical hypothalamus of rats produces anxiety-like states and a similar vulnerability to sodium lactate-induced cardioexcitatory responses. The dorsomedial-perifornical hypothalamus is enriched in neurons containing orexin (ORX, also known as hypocretin), which have a crucial role in arousal, vigilance and central autonomic mobilization, all of which are key components of panic. Here we show that activation of ORX-synthesizing neurons is necessary for developing a panic-prone state in the rat panic model, and either silencing of the hypothalamic gene encoding ORX (Hcrt) with RNAi or systemic ORX-1 receptor antagonists blocks the panic responses. Moreover, we show that human subjects with panic anxiety have elevated levels of ORX in the cerebrospinal fluid compared to subjects without panic anxiety. Taken together, our results suggest that the ORX system may be involved in the pathophysiology of panic anxiety and that ORX antagonists constitute a potential new treatment strategy for panic disorder. Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In individuals with panic disorder there is evidence of decreased central [gamma]-aminobutyric acid (GABA) activity as well as marked increases in autonomic and respiratory responses after intravenous infusions of hypertonic sodium lactate. In a rat model of panic disorder, chronic inhibition of GABA synthesis in the dorsomedial-perifornical hypothalamus of rats produces anxiety-like states and a similar vulnerability to sodium lactate-induced cardioexcitatory responses. The dorsomedial-perifornical hypothalamus is enriched in neurons containing orexin (ORX, also known as hypocretin), which have a crucial role in arousal, vigilance and central autonomic mobilization, all of which are key components of panic. Here we show that activation of ORX-synthesizing neurons is necessary for developing a panic-prone state in the rat panic model, and either silencing of the hypothalamic gene encoding ORX (Hcrt) with RNAi or systemic ORX-1 receptor antagonists blocks the panic responses. Moreover, we show that human subjects with panic anxiety have elevated levels of ORX in the cerebrospinal fluid compared to subjects without panic anxiety. Taken together, our results suggest that the ORX system may be involved in the pathophysiology of panic anxiety and that ORX antagonists constitute a potential new treatment strategy for panic disorder. [PUBLICATION ABSTRACT] Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In individuals with panic disorder there is evidence of decreased central g-aminobutyric acid (GABA) activity as well as marked increases in autonomic and respiratory responses after intravenous infusions of hypertonic sodium lactate. In a rat model of panic disorder, chronic inhibition of GABA synthesis in the dorsomedial-perifornical hypothalamus of rats produces anxiety-like states and a similar vulnerability to sodium lactate-induced cardioexcitatory responses. The dorsomedial-perifornical hypothalamus is enriched in neurons containing orexin (ORX, also known as hypocretin), which have a crucial role in arousal, vigilance and central autonomic mobilization, all of which are key components of panic. Here we show that activation of ORX-synthesizing neurons is necessary for developing a panic-prone state in the rat panic model, and either silencing of the hypothalamic gene encoding ORX (Hcrt) with RNAi or systemic ORX-1 receptor antagonists blocks the panic responses. Moreover, we show that human subjects with panic anxiety have elevated levels of ORX in the cerebrospinal fluid compared to subjects without panic anxiety. Taken together, our results suggest that the ORX system may be involved in the pathophysiology of panic anxiety and that ORX antagonists constitute a potential new treatment strategy for panic disorder. Orexin, a neuropeptide best known for its role in arousal and its absence in people with narcolepsy, is also involved in the pathophysiology of panic anxiety disorder. Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In individuals with panic disorder there is evidence of decreased central γ-aminobutyric acid (GABA) activity as well as marked increases in autonomic and respiratory responses after intravenous infusions of hypertonic sodium lactate 1 , 2 , 3 . In a rat model of panic disorder, chronic inhibition of GABA synthesis in the dorsomedial-perifornical hypothalamus of rats produces anxiety-like states and a similar vulnerability to sodium lactate–induced cardioexcitatory responses 4 , 5 , 6 , 7 , 8 , 9 . The dorsomedial-perifornical hypothalamus is enriched in neurons containing orexin (ORX, also known as hypocretin) 10 , which have a crucial role in arousal 10 , 11 , vigilance 10 and central autonomic mobilization 12 , all of which are key components of panic. Here we show that activation of ORX-synthesizing neurons is necessary for developing a panic-prone state in the rat panic model, and either silencing of the hypothalamic gene encoding ORX ( Hcrt ) with RNAi or systemic ORX-1 receptor antagonists blocks the panic responses. Moreover, we show that human subjects with panic anxiety have elevated levels of ORX in the cerebrospinal fluid compared to subjects without panic anxiety. Taken together, our results suggest that the ORX system may be involved in the pathophysiology of panic anxiety and that ORX antagonists constitute a potential new treatment strategy for panic disorder. |
| Audience | Academic |
| Author | Fitz, Stephanie D Träskman-Bendz, Lil Dietrich, Amy Shekhar, Anantha Brundin, Lena Minick, Pamela E Sanghani, Sonal Truitt, William Johnson, Philip L Goddard, Andrew W |
| AuthorAffiliation | 2 Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, U.S.A 5 Indiana Clinical and Translational Sciences Institute Indianapolis, IN 46202, USA 3 Department of Biochemistry, Indiana University School of Medicine, Indianapolis, IN 46202, U.S.A 1 Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, U.S.A 4 Section of Psychiatry, Department of Clinical Sciences, Lund University Hospital, 221 85 Lund, Sweden |
| AuthorAffiliation_xml | – name: 2 Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, U.S.A – name: 3 Department of Biochemistry, Indiana University School of Medicine, Indianapolis, IN 46202, U.S.A – name: 5 Indiana Clinical and Translational Sciences Institute Indianapolis, IN 46202, USA – name: 4 Section of Psychiatry, Department of Clinical Sciences, Lund University Hospital, 221 85 Lund, Sweden – name: 1 Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, U.S.A |
| Author_xml | – sequence: 1 givenname: Philip L surname: Johnson fullname: Johnson, Philip L organization: Department of Psychiatry, Indiana University School of Medicine – sequence: 2 givenname: William surname: Truitt fullname: Truitt, William organization: Department of Psychiatry, Indiana University School of Medicine, Department of Anatomy and Cell Biology, Indiana University School of Medicine – sequence: 3 givenname: Stephanie D surname: Fitz fullname: Fitz, Stephanie D organization: Department of Psychiatry, Indiana University School of Medicine – sequence: 4 givenname: Pamela E surname: Minick fullname: Minick, Pamela E organization: Department of Psychiatry, Indiana University School of Medicine – sequence: 5 givenname: Amy surname: Dietrich fullname: Dietrich, Amy organization: Department of Psychiatry, Indiana University School of Medicine – sequence: 6 givenname: Sonal surname: Sanghani fullname: Sanghani, Sonal organization: Department of Biochemistry, Indiana University School of Medicine – sequence: 7 givenname: Lil surname: Träskman-Bendz fullname: Träskman-Bendz, Lil organization: Department of Clinical Sciences, Section of Psychiatry, Lund University Hospital – sequence: 8 givenname: Andrew W surname: Goddard fullname: Goddard, Andrew W organization: Department of Psychiatry, Indiana University School of Medicine – sequence: 9 givenname: Lena surname: Brundin fullname: Brundin, Lena organization: Department of Clinical Sciences, Section of Psychiatry, Lund University Hospital – sequence: 10 givenname: Anantha surname: Shekhar fullname: Shekhar, Anantha email: ashekhar@iupui.edu organization: Department of Psychiatry, Indiana University School of Medicine, Indiana Clinical and Translational Sciences Institute |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20037593$$D View this record in MEDLINE/PubMed https://lup.lub.lu.se/record/1547781$$DView record from Swedish Publication Index oai:portal.research.lu.se:publications/06350819-ae00-4d5e-aac9-7d4b7db4c564$$DView record from Swedish Publication Index |
| BookMark | eNqNk2tv0zAUhiM0xC4g_gGqQCrwocOXOHa-IFUTl0mTJnET344c56T1SO3OTmD997i0u2QMNMWRLefxe47znrOf7TjvMMueUnJICVdv3OKQESkeZHtU5MWESvJ9J62JVBNVimI324_xjBDCiSgfZbssraQo-V42no5-4GoUfIujxoeRD3hh3SiNpXbWjLS7sNitHmcPG91GfLKdD7Kv7999Ofo4OTn9cHw0PZkYxVg3yZuqUlSoSktNOZGlQKHLplIVq7kwss7LXFZKVBWlRglhkChT56pByYumkfwg0xvd-AuXfQXLYBc6rMBrC0sfOt1CwIg6mDm0PUSERLXW6M56F4EUXBBFS9BICOS1QNDalJACV7KuciOKPMU4-WeMtl-mt9pq31Pu7UYuaS2wNui6kNIcZD744uwcZv4nMMWZytcCL7cCwZ_3GDtY2GiwbbVD30eQnBecl6xI5Pi_JKNcspRwAp_fAs98H1xyDhjjlBImVYJebKCZbhGsa3xKz6wVYcpoUSgq8zU1uYOaocN0l1SEjU3bA_7wDj49NS6sufPA68GBxHR40c10HyMcf_50f_b025Ad32DnqNtuHn3bbyplAD67aeCVc5dNcv0LTPAxBmzA2O5PxaWr2RYogXUTglvAugmvDb3iLyX_Jl9tSzERbobh2qfb6G-U4DlW |
| CitedBy_id | crossref_primary_10_1016_j_neubiorev_2014_07_027 crossref_primary_10_1038_npp_2013_109 crossref_primary_10_1007_s12264_023_01088_9 crossref_primary_10_1016_j_physbeh_2022_114069 crossref_primary_10_30773_pi_2023_0309 crossref_primary_10_1016_j_celrep_2022_111570 crossref_primary_10_1038_nsmb_3183 crossref_primary_10_1038_s41380_018_0127_0 crossref_primary_10_1016_j_neuroscience_2020_02_026 crossref_primary_10_1080_87559129_2024_2443069 crossref_primary_10_1016_j_biopsych_2021_12_019 crossref_primary_10_1016_j_physbeh_2012_04_016 crossref_primary_10_1155_2018_8120263 crossref_primary_10_1016_j_psyneuen_2013_10_010 crossref_primary_10_1523_ENEURO_0012_18_2018 crossref_primary_10_1016_j_physbeh_2013_10_005 crossref_primary_10_1146_annurev_pharmtox_010716_104837 crossref_primary_10_1038_npp_2014_146 crossref_primary_10_1016_j_neubiorev_2014_03_010 crossref_primary_10_1111_j_1600_0447_2010_01655_x crossref_primary_10_1016_j_bbr_2020_113015 crossref_primary_10_1080_13651501_2021_1927106 crossref_primary_10_1080_23328940_2015_1066921 crossref_primary_10_1016_j_neuropharm_2016_02_018 crossref_primary_10_1124_jpet_114_220392 crossref_primary_10_1016_j_cellsig_2013_07_025 crossref_primary_10_1002_med_21326 crossref_primary_10_3389_fnbeh_2018_00150 crossref_primary_10_1016_j_biopha_2022_112925 crossref_primary_10_1016_j_neuropharm_2023_109815 crossref_primary_10_1016_j_archoralbio_2020_104778 crossref_primary_10_1113_expphysiol_2014_084137 crossref_primary_10_1210_en_2011_1652 crossref_primary_10_1002_cmdc_201900242 crossref_primary_10_1016_j_nsa_2024_104053 crossref_primary_10_1038_s41380_022_01442_9 crossref_primary_10_1016_j_bmcl_2024_129629 crossref_primary_10_1177_2470547017736038 crossref_primary_10_1016_j_euroneuro_2015_12_032 crossref_primary_10_1016_j_yhbeh_2018_09_003 crossref_primary_10_1371_journal_pone_0039131 crossref_primary_10_4103_1673_5374_387969 crossref_primary_10_1016_j_brainres_2018_09_010 crossref_primary_10_1016_j_bbr_2014_10_028 crossref_primary_10_1016_j_gendis_2020_11_013 crossref_primary_10_1016_j_nsa_2023_103922 crossref_primary_10_1021_acsmedchemlett_0c00085 crossref_primary_10_1016_j_neuroscience_2012_05_033 crossref_primary_10_1016_j_resp_2010_04_018 crossref_primary_10_1111_jne_12550 crossref_primary_10_1016_j_brainres_2018_09_011 crossref_primary_10_1097_FBP_0000000000000251 crossref_primary_10_1016_j_pnpbp_2018_01_005 crossref_primary_10_1016_j_neuroscience_2021_08_031 crossref_primary_10_1007_s11920_013_0433_9 crossref_primary_10_1016_j_bbr_2012_06_002 crossref_primary_10_3724_SP_J_1206_2010_00047 crossref_primary_10_1097_WNF_0000000000000499 crossref_primary_10_1016_j_pbb_2011_12_011 crossref_primary_10_1016_j_ejmg_2012_12_005 crossref_primary_10_1002_cne_25231 crossref_primary_10_1038_s41398_024_02769_3 crossref_primary_10_1016_j_bbr_2012_12_064 crossref_primary_10_1152_physrev_00032_2011 crossref_primary_10_1016_j_neuroscience_2017_02_038 crossref_primary_10_1016_j_yhbeh_2011_08_017 crossref_primary_10_1016_j_neuropharm_2018_10_024 crossref_primary_10_1039_c0sc00197j crossref_primary_10_1007_s40495_019_00207_3 crossref_primary_10_1016_j_psyneuen_2014_12_012 crossref_primary_10_1111_febs_16109 crossref_primary_10_1177_0269881112454230 crossref_primary_10_1016_j_brainres_2018_11_032 crossref_primary_10_1111_apha_12963 crossref_primary_10_1007_s00213_014_3520_7 crossref_primary_10_1038_nrn3837 crossref_primary_10_1016_j_npep_2020_102019 crossref_primary_10_1007_s11910_010_0101_y crossref_primary_10_3389_fnbeh_2021_620868 crossref_primary_10_4155_ppa_12_27 crossref_primary_10_1073_pnas_2113518119 crossref_primary_10_1016_j_pbb_2010_08_015 crossref_primary_10_1038_s41386_018_0054_4 crossref_primary_10_1167_iovs_63_3_1 crossref_primary_10_3233_JAD_230527 crossref_primary_10_1021_acs_jmedchem_1c00841 crossref_primary_10_1113_EP092431 crossref_primary_10_1523_JNEUROSCI_3200_12_2013 crossref_primary_10_1111_gbb_12707 crossref_primary_10_1016_j_pnpbp_2022_110517 crossref_primary_10_1517_13543776_2014_978859 crossref_primary_10_1161_HYPERTENSIONAHA_115_07053 crossref_primary_10_1016_j_neubiorev_2014_10_002 crossref_primary_10_1152_ajpregu_00263_2012 crossref_primary_10_17116_jnevro201911904256 crossref_primary_10_1038_npp_2012_38 crossref_primary_10_1016_j_bbr_2010_11_014 crossref_primary_10_1039_D3MD00573A crossref_primary_10_2139_ssrn_4016768 crossref_primary_10_1016_j_pnpbp_2020_110124 crossref_primary_10_1016_j_bmcl_2011_08_094 crossref_primary_10_1111_jne_12403 crossref_primary_10_1016_j_brainres_2019_146359 crossref_primary_10_1016_j_neuroscience_2021_06_006 crossref_primary_10_1007_s11920_015_0639_0 crossref_primary_10_1016_j_physbeh_2012_05_019 crossref_primary_10_1002_hup_2436 crossref_primary_10_1016_j_nlm_2016_10_005 crossref_primary_10_1038_s41583_021_00540_x crossref_primary_10_1016_j_pbb_2014_01_013 crossref_primary_10_1038_s41598_021_95707_y crossref_primary_10_3390_brainsci10120975 crossref_primary_10_3390_brainsci12020150 crossref_primary_10_3389_fphys_2017_01079 crossref_primary_10_1111_jsr_12782 crossref_primary_10_1016_j_brainres_2020_147199 crossref_primary_10_1016_j_pneurobio_2013_12_001 crossref_primary_10_3344_kjp_2022_35_1_22 crossref_primary_10_1039_c003468a crossref_primary_10_1371_journal_pone_0039982 crossref_primary_10_3389_fnins_2020_00691 crossref_primary_10_1016_j_brainres_2018_12_036 crossref_primary_10_1016_j_physbeh_2014_04_006 crossref_primary_10_1097_JCP_0000000000000139 crossref_primary_10_1111_bph_12415 crossref_primary_10_1007_s00441_013_1610_1 crossref_primary_10_1016_j_tins_2015_06_005 crossref_primary_10_1021_cn5001028 crossref_primary_10_1016_j_pharep_2015_09_002 crossref_primary_10_1016_j_yhbeh_2013_12_014 crossref_primary_10_3390_molecules28083575 crossref_primary_10_1002_da_22403 crossref_primary_10_1016_j_psyneuen_2021_105317 crossref_primary_10_1016_j_bbr_2018_05_032 crossref_primary_10_1007_s00213_018_4871_2 crossref_primary_10_1080_13651501_2019_1711425 crossref_primary_10_3389_fneur_2018_00413 crossref_primary_10_1113_JP271946 crossref_primary_10_1517_13543784_2014_996286 crossref_primary_10_1016_j_physbeh_2020_112988 crossref_primary_10_1038_s41598_024_52465_x crossref_primary_10_1016_j_neubiorev_2021_104516 crossref_primary_10_7759_cureus_30788 crossref_primary_10_1016_j_neuropharm_2014_09_012 crossref_primary_10_1016_j_npep_2018_12_001 crossref_primary_10_1016_j_physbeh_2013_03_023 crossref_primary_10_1007_s40263_014_0179_x crossref_primary_10_1016_j_neuint_2017_12_006 crossref_primary_10_1016_j_neubiorev_2020_07_040 crossref_primary_10_1016_j_str_2023_12_008 crossref_primary_10_1016_j_sleep_2022_10_016 crossref_primary_10_1016_j_molmed_2022_10_008 crossref_primary_10_1016_j_pbb_2015_09_021 crossref_primary_10_1016_j_physbeh_2012_02_010 crossref_primary_10_1016_j_expneurol_2022_114250 crossref_primary_10_1016_j_physbeh_2016_10_008 crossref_primary_10_1016_j_bmcl_2013_06_057 crossref_primary_10_1038_s41398_019_0415_8 crossref_primary_10_1016_j_medidd_2020_100059 crossref_primary_10_1016_j_neuropharm_2024_109949 crossref_primary_10_1111_bph_17325 crossref_primary_10_1016_j_biopsych_2016_06_010 crossref_primary_10_1016_j_npep_2021_102127 crossref_primary_10_3389_fnins_2018_00295 crossref_primary_10_1371_journal_pone_0040625 crossref_primary_10_1016_j_yfrne_2023_101066 crossref_primary_10_1016_S1474_4422_14_70218_2 crossref_primary_10_1177_02698811231167989 crossref_primary_10_1038_s41398_020_00937_9 crossref_primary_10_1111_j_1365_2826_2012_02369_x crossref_primary_10_1016_j_pbb_2013_05_013 crossref_primary_10_5498_wjp_v6_i1_43 crossref_primary_10_1016_j_bbr_2016_12_007 crossref_primary_10_1016_j_ajme_2014_07_002 crossref_primary_10_1016_j_pnpbp_2020_110166 crossref_primary_10_1016_j_neuroscience_2019_08_026 crossref_primary_10_1371_journal_pone_0126719 crossref_primary_10_1016_j_yfrne_2018_06_003 crossref_primary_10_7202_1014945ar crossref_primary_10_1038_npp_2012_70 crossref_primary_10_1210_endrev_bnab042 crossref_primary_10_3389_fnins_2019_00702 crossref_primary_10_1016_j_psyneuen_2015_12_011 crossref_primary_10_1016_j_aquatox_2012_11_011 crossref_primary_10_1002_da_21925 crossref_primary_10_1017_S0954579416000699 crossref_primary_10_1038_nrn2801 crossref_primary_10_3389_fneur_2015_00032 crossref_primary_10_1038_npp_2012_76 crossref_primary_10_1002_med_21959 crossref_primary_10_1007_s12264_019_00447_9 crossref_primary_10_1111_joim_13406 crossref_primary_10_1007_s40263_013_0064_z crossref_primary_10_1038_ncomms7266 crossref_primary_10_1016_j_crfs_2024_100754 crossref_primary_10_1523_JNEUROSCI_1130_13_2013 crossref_primary_10_1016_j_bbr_2011_03_028 crossref_primary_10_2142_biophys_64_263 crossref_primary_10_1016_j_cub_2016_07_013 crossref_primary_10_1038_s41380_018_0119_0 crossref_primary_10_1007_s00213_012_2736_7 crossref_primary_10_30773_pi_2018_08_21_1 crossref_primary_10_1038_tp_2015_67 crossref_primary_10_1038_s41598_023_49809_4 crossref_primary_10_1152_jn_00213_2015 crossref_primary_10_3389_fnsys_2015_00009 crossref_primary_10_1016_j_medidd_2020_100070 crossref_primary_10_1038_npp_2012_48 crossref_primary_10_26599_SAB_2022_9060019 crossref_primary_10_1111_jsr_13825 crossref_primary_10_1038_s41380_017_0006_0 crossref_primary_10_1155_2011_531435 crossref_primary_10_1016_j_neuropharm_2010_12_026 crossref_primary_10_1038_s41592_021_01390_2 crossref_primary_10_1038_s41398_020_01076_x crossref_primary_10_1021_bi300136h crossref_primary_10_1002_cmdc_201402258 crossref_primary_10_1038_s41380_022_01574_y crossref_primary_10_3389_fnmol_2023_1140672 crossref_primary_10_1016_j_brainres_2018_07_026 crossref_primary_10_1016_j_bmcl_2023_129151 crossref_primary_10_1073_pnas_1320325110 crossref_primary_10_1007_s10571_017_0487_z crossref_primary_10_3389_fphys_2024_1341649 crossref_primary_10_4155_ppa_14_46 crossref_primary_10_1073_pnas_1800455115 crossref_primary_10_1016_j_cbpc_2023_109555 crossref_primary_10_1016_j_neuroscience_2024_11_031 crossref_primary_10_1038_s41398_022_02090_x crossref_primary_10_1007_s40263_022_00974_6 crossref_primary_10_1016_j_peptides_2021_170629 crossref_primary_10_1016_j_neuropharm_2018_11_017 crossref_primary_10_1016_j_physbeh_2012_03_016 crossref_primary_10_1038_s41593_017_0023_y crossref_primary_10_20900_jpbs_20190004 crossref_primary_10_1016_j_bpsgos_2024_100310 crossref_primary_10_1111_bcp_14251 crossref_primary_10_3390_biom14020163 crossref_primary_10_1016_j_neuroscience_2014_04_069 crossref_primary_10_1016_j_regpep_2014_11_003 crossref_primary_10_4102_jomped_v4i1_97 crossref_primary_10_1007_s00429_013_0626_3 crossref_primary_10_1039_C5MD00074B crossref_primary_10_1016_j_neuropharm_2018_09_034 crossref_primary_10_1517_14728214_2011_628313 crossref_primary_10_1016_j_bbr_2019_112455 crossref_primary_10_1016_j_tips_2011_03_007 crossref_primary_10_1016_j_neubiorev_2023_105107 crossref_primary_10_1016_j_resp_2010_02_006 crossref_primary_10_1038_s41386_024_01937_9 crossref_primary_10_2147_JEP_S261403 crossref_primary_10_1016_j_neubiorev_2016_06_044 crossref_primary_10_1016_j_neuroscience_2016_02_066 crossref_primary_10_1002_jnr_25322 crossref_primary_10_1111_j_1460_9568_2010_07401_x crossref_primary_10_1152_ajpcell_00227_2012 crossref_primary_10_1111_ejn_12101 crossref_primary_10_1007_s41782_017_0032_7 crossref_primary_10_1016_j_brainresbull_2023_110712 crossref_primary_10_1016_j_celrep_2020_107779 crossref_primary_10_1016_j_janxdis_2010_10_013 crossref_primary_10_1124_pr_111_005546 crossref_primary_10_3389_fneur_2023_1107632 crossref_primary_10_31887_DCNS_2011_13_4_jwemmie crossref_primary_10_1186_s12014_019_9259_8 crossref_primary_10_1007_s00213_014_3769_x crossref_primary_10_3390_bs12080262 crossref_primary_10_1038_tp_2016_162 crossref_primary_10_1021_acs_jmedchem_2c01773 crossref_primary_10_1080_14737175_2023_2211767 crossref_primary_10_1007_s12035_012_8255_z crossref_primary_10_1016_j_bmcl_2022_128555 crossref_primary_10_1002_cmdc_201000132 crossref_primary_10_3389_fnins_2015_00065 crossref_primary_10_1007_s00424_013_1271_7 crossref_primary_10_1016_j_neubiorev_2015_08_005 crossref_primary_10_3389_fphar_2017_00357 crossref_primary_10_1038_ncomms2461 crossref_primary_10_1016_j_neuropharm_2018_09_016 crossref_primary_10_1113_jphysiol_2013_256271 crossref_primary_10_1113_JP272199 crossref_primary_10_1016_j_yhbeh_2019_104584 crossref_primary_10_3389_fphys_2023_1183933 crossref_primary_10_1007_s00429_023_02691_2 |
| Cites_doi | 10.1016/j.euroneuro.2007.01.005 10.1016/S0091-3057(96)00077-9 10.1001/archpsyc.58.6.556 10.1523/JNEUROSCI.2491-06.2006 10.1097/00004714-198602000-00001 10.1523/JNEUROSCI.17-24-09726.1997 10.1176/ajp.143.4.495 10.1016/j.bbr.2004.07.012 10.1152/ajpregu.00667.2003 10.1016/0006-3223(91)90069-X 10.1038/sj.npp.1301621 10.1016/S0014-2999(03)01278-0 10.1176/appi.ajp.161.12.2186 10.1152/ajpregu.00671.2002 10.1016/0006-3223(94)90040-X 10.1038/nrn2092 10.1016/S0140-6736(06)69418-X 10.1176/ajp.151.4.547 10.1126/science.1175055 10.1016/S0006-3223(02)01740-7 10.1111/j.1749-6632.2003.tb07090.x 10.1002/da.10026 10.1038/nm1544 10.1016/S0006-3223(02)01355-0 10.1590/S0100-879X2001000200001 10.1523/JNEUROSCI.0408-06.2006 10.1016/S0028-3908(99)00215-4 10.1016/S0091-3022(03)00028-1 10.1523/JNEUROSCI.21-19-j0003.2001 10.1073/pnas.95.1.322 |
| ContentType | Journal Article |
| Copyright | Springer Nature America, Inc. 2009 COPYRIGHT 2010 Nature Publishing Group Copyright Nature Publishing Group Jan 2010 |
| Copyright_xml | – notice: Springer Nature America, Inc. 2009 – notice: COPYRIGHT 2010 Nature Publishing Group – notice: Copyright Nature Publishing Group Jan 2010 |
| CorporateAuthor | Psykiatri, Lund Institutionen för kliniska vetenskaper, Lund MultiPark: Multidisciplinary research focused on Parkinson's disease Psychiatry (Lund) Lunds universitet Profile areas and other strong research environments Lund University Department of Clinical Sciences, Lund Strategiska forskningsområden (SFO) Faculty of Medicine Strategic research areas (SRA) Section IV Medicinska fakulteten Sektion IV Profilområden och andra starka forskningsmiljöer |
| CorporateAuthor_xml | – name: Faculty of Medicine – name: Medicinska fakulteten – name: Strategiska forskningsområden (SFO) – name: Institutionen för kliniska vetenskaper, Lund – name: Strategic research areas (SRA) – name: Lunds universitet – name: Department of Clinical Sciences, Lund – name: Sektion IV – name: Profilområden och andra starka forskningsmiljöer – name: Lund University – name: Section IV – name: Psychiatry (Lund) – name: Psykiatri, Lund – name: Profile areas and other strong research environments – name: MultiPark: Multidisciplinary research focused on Parkinson's disease |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QP 7QR 7T5 7TK 7TM 7TO 7U7 7U9 7X7 7XB 88A 88E 88I 8AO 8FD 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. LK8 M0S M1P M2O M2P M7N M7P MBDVC P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U RC3 7X8 5PM ADTPV AOWAS D95 |
| DOI | 10.1038/nm.2075 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Toxicology Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Journals Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Research Library ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Central Korea Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Research Library Science Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Research Library (Corporate) Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) SwePub SwePub Articles SWEPUB Lunds universitet |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Central Basic Toxicology Abstracts ProQuest Science Journals ProQuest SciTech Collection ProQuest Medical Library Animal Behavior Abstracts Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE Research Library Prep Neurosciences Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1546-170X |
| EndPage | 115 |
| ExternalDocumentID | oai_portal_research_lu_se_publications_06350819_ae00_4d5e_aac9_7d4b7db4c564 oai_lup_lub_lu_se_06350819_ae00_4d5e_aac9_7d4b7db4c564 PMC2832844 1937634231 A216681748 20037593 10_1038_nm_2075 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GeographicLocations | United States |
| GeographicLocations_xml | – name: United States |
| GrantInformation_xml | – fundername: NIMH NIH HHS grantid: R01 MH052619 – fundername: NIMH NIH HHS grantid: R01 MH52619 – fundername: NIMH NIH HHS grantid: R01 MH065702 – fundername: NCATS NIH HHS grantid: UL1 TR001108 – fundername: NCRR NIH HHS grantid: UL1 RR025761 – fundername: NCRR NIH HHS grantid: UL1RR025761 |
| GroupedDBID | --- .-4 .55 .GJ 0R~ 123 1CY 29M 2FS 36B 39C 3O- 3V. 4.4 53G 5BI 5M7 5RE 5S5 70F 7X7 85S 88A 88E 88I 8AO 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 AAEEF AARCD AAYOK AAYZH AAZLF ABAWZ ABCQX ABDBF ABDPE ABEFU ABJNI ABLJU ABOCM ABUWG ACBWK ACGFO ACGFS ACGOD ACIWK ACMJI ACPRK ACUHS ADBBV ADFRT AENEX AEUYN AFBBN AFKRA AFRAH AFSHS AGAYW AGCDD AGHTU AHBCP AHMBA AHOSX AHSBF AIBTJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH ARMCB ASPBG AVWKF AXYYD AZFZN AZQEC B0M BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU CS3 DB5 DU5 DWQXO EAD EAP EBC EBD EBS EE. EJD EMB EMK EMOBN EPL ESX EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH GX1 HCIFZ HMCUK HVGLF HZ~ IAO IEA IH2 IHR IHW INH INR IOF IOV ISR ITC J5H L7B LGEZI LK8 LOTEE M0L M1P M2O M2P M7P MK0 N9A NADUK NNMJJ NXXTH O9- ODYON P2P PQQKQ PROAC PSQYO Q2X RIG RNS RNT RNTTT RVV SHXYY SIXXV SJN SNYQT SOJ SV3 TAE TAOOD TBHMF TDRGL TSG TUS UKHRP UQL X7M XJT YHZ ZGI ~8M AAYXX ABFSG ACMFV ACSTC AETEA AFANA ALPWD ATHPR CITATION PHGZM PHGZT AEZWR AFHIU AHWEU AIXLP CGR CUY CVF ECM EIF NFIDA NPM PJZUB PPXIY PQGLB AEIIB PMFND 7QG 7QL 7QP 7QR 7T5 7TK 7TM 7TO 7U7 7U9 7XB 8FD 8FK C1K FR3 H94 K9. M7N MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 7X8 5PM ADTPV AOWAS D95 PUEGO |
| ID | FETCH-LOGICAL-c822t-4fbb8158ba7a130795e5a9fb8b2d35c7d4947b85bb11c855ce08cd48fe736ff73 |
| IEDL.DBID | 7X7 |
| ISSN | 1078-8956 1546-170X |
| IngestDate | Sat Aug 30 03:21:41 EDT 2025 Thu Jul 03 05:09:22 EDT 2025 Thu Aug 21 18:11:32 EDT 2025 Tue Aug 05 10:54:46 EDT 2025 Fri Jul 11 04:51:40 EDT 2025 Sat Aug 16 21:31:18 EDT 2025 Tue Jun 17 21:25:13 EDT 2025 Thu Jun 12 23:50:45 EDT 2025 Tue Jun 10 20:19:13 EDT 2025 Thu Jul 31 10:26:00 EDT 2025 Fri Jun 27 03:32:09 EDT 2025 Thu May 22 21:09:48 EDT 2025 Mon Jul 21 06:01:22 EDT 2025 Thu Apr 24 22:50:29 EDT 2025 Tue Jul 01 03:53:31 EDT 2025 Fri Feb 21 02:39:14 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | http://www.springer.com/tdm Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c822t-4fbb8158ba7a130795e5a9fb8b2d35c7d4947b85bb11c855ce08cd48fe736ff73 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 both authors made equal contribution to this report AUTHOR CONTRIBUTIONS AS, PLJ, and WT formulated the hypotheses and designed the studies. SDF and PLJ performed telemetrical probe surgeries. SDF and PLJ scored all behavior and SDF performed all stereotaxic surgeries. PLJ performed the immunohistochemistry. PEM and AD performed all RT-PCR assays with technical expertise from WT and SS. PLJ and WT analyzed all animal data. LT-B and LB were responsible for the human subject study, the ORX assays of the CSF samples and the analysis of the human data. PLJ, WT and AS interpreted the data and collectively wrote the main draft of the article. PJ, WT, SDF, AD, PK, LB, LT-B, AG and AS contributed to the writing of the manuscript and have approved of the final version. |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC2832844 |
| PMID | 20037593 |
| PQID | 223110278 |
| PQPubID | 33975 |
| PageCount | 5 |
| ParticipantIDs | swepub_primary_oai_portal_research_lu_se_publications_06350819_ae00_4d5e_aac9_7d4b7db4c564 swepub_primary_oai_lup_lub_lu_se_06350819_ae00_4d5e_aac9_7d4b7db4c564 pubmedcentral_primary_oai_pubmedcentral_nih_gov_2832844 proquest_miscellaneous_733633926 proquest_miscellaneous_21372081 proquest_journals_223110278 gale_infotracmisc_A216681748 gale_infotracgeneralonefile_A216681748 gale_infotracacademiconefile_A216681748 gale_incontextgauss_ISR_A216681748 gale_incontextgauss_IOV_A216681748 gale_healthsolutions_A216681748 pubmed_primary_20037593 crossref_citationtrail_10_1038_nm_2075 crossref_primary_10_1038_nm_2075 springer_journals_10_1038_nm_2075 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2010-01-01 |
| PublicationDateYYYYMMDD | 2010-01-01 |
| PublicationDate_xml | – month: 01 year: 2010 text: 2010-01-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | New York |
| PublicationPlace_xml | – name: New York – name: United States |
| PublicationTitle | Nature medicine |
| PublicationTitleAbbrev | Nat Med |
| PublicationTitleAlternate | Nat Med |
| PublicationYear | 2010 |
| Publisher | Nature Publishing Group US Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group US – name: Nature Publishing Group |
| References | Liebowitz (CR14) 1986; 143 Cowley, Dager, Roy-Byrne, Avery, Dunner (CR15) 1991; 30 de Lecea (CR19) 1998; 95 Ludewig, Ludewig, Geyer, Hell, Vollenweider (CR28) 2002; 15 Rupprecht (CR24) 2009; 325 Roy-Byrne, Craske, Stein (CR3) 2006; 368 CR13 Johnson, Truitt, Fitz, Lowry, Shekhar (CR5) 2008; 33 Liebowitz (CR16) 1986; 6 Sakurai (CR10) 2007; 8 Salomon (CR29) 2003; 54 Shekhar, Keim, Simon, McBride (CR9) 1996; 55 Ferguson, Samson (CR12) 2003; 24 Ishii (CR22) 2005; 157 Kayaba (CR20) 2003; 285 Brundin, Bjorkqvist, Petersen, Traskman-Bendz (CR30) 2007; 17 Chou (CR21) 2001; 21 Grillon, Ameli, Goddard, Woods, Davis (CR27) 1994; 35 Goddard (CR1) 2001; 58 Shekhar, Keim (CR7) 1997; 17 Samuels, Zaretsky, DiMicco (CR31) 2004; 287 Boshuisen, Ter Horst, Paans, Reinders, den Boer (CR26) 2002; 52 Brisbare-Roch (CR11) 2007; 13 Andreatini (CR25) 2001; 34 Shekhar, Keim, Simon, McBride (CR32) 1996; 55 Goddard (CR2) 2004; 161 Shekhar, Sajdyk, Gehlert, Rainnie (CR18) 2003; 985 Johnson, Truitt, Fitz, Lowry, Shekhar (CR23) 2007; 33 Gorman (CR17) 1994; 151 Shekhar (CR6) 2006; 26 Johnson, Shekhar (CR4) 2006; 26 De Boer, Koolhaas (CR33) 2003; 463 Shekhar, Keim (CR8) 2000; 39 Y Kayaba (BFnm2075_CR20) 2003; 285 A Shekhar (BFnm2075_CR32) 1996; 55 DS Cowley (BFnm2075_CR15) 1991; 30 AV Ferguson (BFnm2075_CR12) 2003; 24 BC Samuels (BFnm2075_CR31) 2004; 287 A Shekhar (BFnm2075_CR6) 2006; 26 MR Liebowitz (BFnm2075_CR16) 1986; 6 L Brundin (BFnm2075_CR30) 2007; 17 RM Salomon (BFnm2075_CR29) 2003; 54 BFnm2075_CR13 L de Lecea (BFnm2075_CR19) 1998; 95 PP Roy-Byrne (BFnm2075_CR3) 2006; 368 Y Ishii (BFnm2075_CR22) 2005; 157 A Shekhar (BFnm2075_CR7) 1997; 17 AW Goddard (BFnm2075_CR1) 2001; 58 JM Gorman (BFnm2075_CR17) 1994; 151 C Grillon (BFnm2075_CR27) 1994; 35 T Sakurai (BFnm2075_CR10) 2007; 8 PL Johnson (BFnm2075_CR5) 2008; 33 A Shekhar (BFnm2075_CR18) 2003; 985 A Shekhar (BFnm2075_CR8) 2000; 39 S Ludewig (BFnm2075_CR28) 2002; 15 AW Goddard (BFnm2075_CR2) 2004; 161 ML Boshuisen (BFnm2075_CR26) 2002; 52 MR Liebowitz (BFnm2075_CR14) 1986; 143 A Shekhar (BFnm2075_CR9) 1996; 55 SF De Boer (BFnm2075_CR33) 2003; 463 C Brisbare-Roch (BFnm2075_CR11) 2007; 13 PL Johnson (BFnm2075_CR23) 2007; 33 R Andreatini (BFnm2075_CR25) 2001; 34 TC Chou (BFnm2075_CR21) 2001; 21 PL Johnson (BFnm2075_CR4) 2006; 26 R Rupprecht (BFnm2075_CR24) 2009; 325 |
| References_xml | – volume: 17 start-page: 573 year: 2007 end-page: 579 ident: CR30 article-title: Reduced orexin levels in the cerebrospinal fluid of suicidal patients with major depressive disorder publication-title: Eur. Neuropsychopharmacol. doi: 10.1016/j.euroneuro.2007.01.005 – volume: 55 start-page: 249 year: 1996 end-page: 256 ident: CR32 article-title: Dorsomedial hypothalamic GABA dysfunction produces physiological arousal following sodium lactate infusions publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/S0091-3057(96)00077-9 – volume: 58 start-page: 556 year: 2001 end-page: 561 ident: CR1 article-title: Reductions in occipital cortex GABA levels in panic disorder detected with 1h-magnetic resonance spectroscopy publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.58.6.556 – volume: 26 start-page: 9205 year: 2006 end-page: 9215 ident: CR6 article-title: Angiotensin-II is a putative neurotransmitter in lactate-induced panic-like responses in rats with disruption of GABAergic inhibition in the dorsomedial hypothalamus publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2491-06.2006 – volume: 6 start-page: 13 year: 1986 end-page: 20 ident: CR16 article-title: Alprazolam in the treatment of panic disorders publication-title: J. Clin. Psychopharmacol. doi: 10.1097/00004714-198602000-00001 – volume: 17 start-page: 9726 year: 1997 end-page: 9735 ident: CR7 article-title: The circumventricular organs form a potential neural pathway for lactate sensitivity: implications for panic disorder publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.17-24-09726.1997 – volume: 143 start-page: 495 year: 1986 end-page: 502 ident: CR14 article-title: Possible mechanisms for lactate's induction of panic publication-title: Am. J. Psychiatry doi: 10.1176/ajp.143.4.495 – volume: 157 start-page: 331 year: 2005 end-page: 341 ident: CR22 article-title: Anorexia and weight loss in male rats 24 h following single dose treatment with orexin-1 receptor antagonist SB-334867 publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2004.07.012 – volume: 287 start-page: R472 year: 2004 end-page: R478 ident: CR31 article-title: Dorsomedial hypothalamic sites where disinhibition evokes tachycardia correlate with location of raphe-projecting neurons publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol. doi: 10.1152/ajpregu.00667.2003 – volume: 30 start-page: 49 year: 1991 end-page: 56 ident: CR15 article-title: Lactate vulnerability after alprazolam versus placebo treatment of panic disorder publication-title: Biol. Psychiatry doi: 10.1016/0006-3223(91)90069-X – volume: 33 start-page: 2093 year: 2008 end-page: 2107 ident: CR5 article-title: Neural pathways underlying lactate-induced panic publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1301621 – volume: 463 start-page: 145 year: 2003 end-page: 161 ident: CR33 article-title: Defensive burying in rodents: ethology, neurobiology and psychopharmacology publication-title: Eur. J. Pharmacol. doi: 10.1016/S0014-2999(03)01278-0 – volume: 161 start-page: 2186 year: 2004 end-page: 2193 ident: CR2 article-title: Impaired GABA neuronal response to acute benzodiazepine administration in panic disorder publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.161.12.2186 – volume: 285 start-page: R581 year: 2003 end-page: R593 ident: CR20 article-title: Attenuated defense response and low basal blood pressure in orexin knockout mice publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol. doi: 10.1152/ajpregu.00671.2002 – volume: 35 start-page: 431 year: 1994 end-page: 439 ident: CR27 article-title: Baseline and fear-potentiated startle in panic disorder patients publication-title: Biol. Psychiatry doi: 10.1016/0006-3223(94)90040-X – volume: 8 start-page: 171 year: 2007 end-page: 181 ident: CR10 article-title: The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn2092 – volume: 368 start-page: 1023 year: 2006 end-page: 1032 ident: CR3 article-title: Panic disorder publication-title: Lancet doi: 10.1016/S0140-6736(06)69418-X – volume: 151 start-page: 547 year: 1994 end-page: 553 ident: CR17 article-title: Anxiogenic effects of CO2 and hyperventilation in patients with panic disorder publication-title: Am. J. Psychiatry doi: 10.1176/ajp.151.4.547 – volume: 325 start-page: 490 year: 2009 end-page: 493 ident: CR24 article-title: Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects publication-title: Science doi: 10.1126/science.1175055 – volume: 54 start-page: 96 year: 2003 end-page: 104 ident: CR29 article-title: Diurnal variation of cerebrospinal fluid hypocretin-1 (Orexin-A) levels in control and depressed subjects publication-title: Biol. Psychiatry doi: 10.1016/S0006-3223(02)01740-7 – volume: 985 start-page: 308 year: 2003 end-page: 325 ident: CR18 article-title: The amygdala, panic disorder, and cardiovascular responses publication-title: Ann. NY Acad. Sci. doi: 10.1111/j.1749-6632.2003.tb07090.x – volume: 15 start-page: 55 year: 2002 end-page: 60 ident: CR28 article-title: Prepulse inhibition deficits in patients with panic disorder publication-title: Depress. Anxiety doi: 10.1002/da.10026 – volume: 13 start-page: 150 year: 2007 end-page: 155 ident: CR11 article-title: Promotion of sleep by targeting the orexin system in rats, dogs and humans publication-title: Nat. Med. doi: 10.1038/nm1544 – volume: 52 start-page: 126 year: 2002 end-page: 135 ident: CR26 article-title: rCBF differences between panic disorder patients and control subjects during anticipatory anxiety and rest publication-title: Biol. Psychiatry doi: 10.1016/S0006-3223(02)01355-0 – ident: CR13 – volume: 34 start-page: 145 year: 2001 end-page: 154 ident: CR25 article-title: The brain decade in debate: II. Panic or anxiety? From animal models to a neurobiological basis publication-title: Braz. J. Med. Biol. Res. doi: 10.1590/S0100-879X2001000200001 – volume: 26 start-page: 7093 year: 2006 end-page: 7104 ident: CR4 article-title: Panic-prone state induced in rats with GABA dysfunction in the dorsomedial hypothalamus is mediated by NMDA receptors publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0408-06.2006 – volume: 39 start-page: 1139 year: 2000 end-page: 1146 ident: CR8 article-title: LY354740, a potent group II metabotropic glutamate receptor agonist prevents lactate-induced panic-like response in panic-prone rats publication-title: Neuropharmacology doi: 10.1016/S0028-3908(99)00215-4 – volume: 24 start-page: 141 year: 2003 end-page: 150 ident: CR12 article-title: The orexin/hypocretin system: a critical regulator of neuroendocrine and autonomic function publication-title: Front. Neuroendocrinol. doi: 10.1016/S0091-3022(03)00028-1 – volume: 33 start-page: 2093 year: 2007 end-page: 2107 ident: CR23 article-title: Neural pathways underlying lactate-induced panic publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1301621 – volume: 55 start-page: 249 year: 1996 end-page: 256 ident: CR9 article-title: Dorsomedial hypothalamic GABA dysfunction produces physiological arousal following sodium lactate infusions publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/S0091-3057(96)00077-9 – volume: 21 start-page: RC168 year: 2001 ident: CR21 article-title: Orexin (hypocretin) neurons contain dynorphin publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.21-19-j0003.2001 – volume: 95 start-page: 322 year: 1998 end-page: 327 ident: CR19 article-title: The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.95.1.322 – volume: 26 start-page: 9205 year: 2006 ident: BFnm2075_CR6 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2491-06.2006 – volume: 151 start-page: 547 year: 1994 ident: BFnm2075_CR17 publication-title: Am. J. Psychiatry doi: 10.1176/ajp.151.4.547 – volume: 463 start-page: 145 year: 2003 ident: BFnm2075_CR33 publication-title: Eur. J. Pharmacol. doi: 10.1016/S0014-2999(03)01278-0 – volume: 21 start-page: RC168 year: 2001 ident: BFnm2075_CR21 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.21-19-j0003.2001 – volume: 55 start-page: 249 year: 1996 ident: BFnm2075_CR32 publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/S0091-3057(96)00077-9 – volume: 287 start-page: R472 year: 2004 ident: BFnm2075_CR31 publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol. doi: 10.1152/ajpregu.00667.2003 – volume: 325 start-page: 490 year: 2009 ident: BFnm2075_CR24 publication-title: Science doi: 10.1126/science.1175055 – volume: 33 start-page: 2093 year: 2008 ident: BFnm2075_CR5 publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1301621 – volume: 157 start-page: 331 year: 2005 ident: BFnm2075_CR22 publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2004.07.012 – volume: 39 start-page: 1139 year: 2000 ident: BFnm2075_CR8 publication-title: Neuropharmacology doi: 10.1016/S0028-3908(99)00215-4 – volume: 15 start-page: 55 year: 2002 ident: BFnm2075_CR28 publication-title: Depress. Anxiety doi: 10.1002/da.10026 – volume: 30 start-page: 49 year: 1991 ident: BFnm2075_CR15 publication-title: Biol. Psychiatry doi: 10.1016/0006-3223(91)90069-X – volume: 368 start-page: 1023 year: 2006 ident: BFnm2075_CR3 publication-title: Lancet doi: 10.1016/S0140-6736(06)69418-X – volume: 17 start-page: 573 year: 2007 ident: BFnm2075_CR30 publication-title: Eur. Neuropsychopharmacol. doi: 10.1016/j.euroneuro.2007.01.005 – volume: 17 start-page: 9726 year: 1997 ident: BFnm2075_CR7 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.17-24-09726.1997 – volume: 6 start-page: 13 year: 1986 ident: BFnm2075_CR16 publication-title: J. Clin. Psychopharmacol. doi: 10.1097/00004714-198602000-00001 – volume: 95 start-page: 322 year: 1998 ident: BFnm2075_CR19 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.95.1.322 – volume: 35 start-page: 431 year: 1994 ident: BFnm2075_CR27 publication-title: Biol. Psychiatry doi: 10.1016/0006-3223(94)90040-X – volume: 8 start-page: 171 year: 2007 ident: BFnm2075_CR10 publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn2092 – volume: 26 start-page: 7093 year: 2006 ident: BFnm2075_CR4 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0408-06.2006 – volume: 55 start-page: 249 year: 1996 ident: BFnm2075_CR9 publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/S0091-3057(96)00077-9 – volume: 985 start-page: 308 year: 2003 ident: BFnm2075_CR18 publication-title: Ann. NY Acad. Sci. doi: 10.1111/j.1749-6632.2003.tb07090.x – volume: 52 start-page: 126 year: 2002 ident: BFnm2075_CR26 publication-title: Biol. Psychiatry doi: 10.1016/S0006-3223(02)01355-0 – volume: 33 start-page: 2093 year: 2007 ident: BFnm2075_CR23 publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1301621 – volume: 54 start-page: 96 year: 2003 ident: BFnm2075_CR29 publication-title: Biol. Psychiatry doi: 10.1016/S0006-3223(02)01740-7 – volume: 161 start-page: 2186 year: 2004 ident: BFnm2075_CR2 publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.161.12.2186 – volume: 24 start-page: 141 year: 2003 ident: BFnm2075_CR12 publication-title: Front. Neuroendocrinol. doi: 10.1016/S0091-3022(03)00028-1 – volume: 285 start-page: R581 year: 2003 ident: BFnm2075_CR20 publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol. doi: 10.1152/ajpregu.00671.2002 – ident: BFnm2075_CR13 – volume: 58 start-page: 556 year: 2001 ident: BFnm2075_CR1 publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.58.6.556 – volume: 143 start-page: 495 year: 1986 ident: BFnm2075_CR14 publication-title: Am. J. Psychiatry doi: 10.1176/ajp.143.4.495 – volume: 34 start-page: 145 year: 2001 ident: BFnm2075_CR25 publication-title: Braz. J. Med. Biol. Res. doi: 10.1590/S0100-879X2001000200001 – volume: 13 start-page: 150 year: 2007 ident: BFnm2075_CR11 publication-title: Nat. Med. doi: 10.1038/nm1544 |
| SSID | ssj0003059 |
| Score | 2.478039 |
| Snippet | Orexin, a neuropeptide best known for its role in arousal and its absence in people with narcolepsy, is also involved in the pathophysiology of panic anxiety... Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In individuals with panic disorder there is evidence of decreased... Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In subjects with panic disorder there is evidence of decreased central... |
| SourceID | swepub pubmedcentral proquest gale pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 111 |
| SubjectTerms | Adult Alprazolam - pharmacology Analysis Animals Anxiety Anxiety - drug therapy Anxiety - physiopathology Biomedical and Life Sciences Biomedicine Cancer Research Clinical Medicine Disease Models, Animal Female GABA Genetic aspects Hormones Humans Hypothalamus - physiology Infectious Diseases Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - cerebrospinal fluid Intracellular Signaling Peptides and Proteins - physiology Klinisk medicin letter Male Medical and Health Sciences Medicin och hälsovetenskap Metabolic Diseases Middle Aged Molecular Medicine Neurons Neurons - drug effects Neurons - physiology Neuropeptides - antagonists & inhibitors Neuropeptides - cerebrospinal fluid Neuropeptides - physiology Neurosciences Neurotransmitter Agents - physiology Neurotransmitters Orexin Receptors Orexins Panic attacks Panic Disorder - cerebrospinal fluid Panic Disorder - drug therapy Panic Disorder - physiopathology Physiological aspects Psychiatry Psykiatri Rats Receptors, G-Protein-Coupled - drug effects Receptors, G-Protein-Coupled - physiology Receptors, Neuropeptide - drug effects Receptors, Neuropeptide - physiology Risk factors Rodents Sodium Sodium Lactate - pharmacology |
| Title | A key role for orexin in panic anxiety |
| URI | https://link.springer.com/article/10.1038/nm.2075 https://www.ncbi.nlm.nih.gov/pubmed/20037593 https://www.proquest.com/docview/223110278 https://www.proquest.com/docview/21372081 https://www.proquest.com/docview/733633926 https://pubmed.ncbi.nlm.nih.gov/PMC2832844 https://lup.lub.lu.se/record/1547781 oai:portal.research.lu.se:publications/06350819-ae00-4d5e-aac9-7d4b7db4c564 |
| Volume | 16 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELdgE4gXBOMrbIyAUHmKlg87dp5QQZ0G0gYaDFW8WLbjbJVGUtZWGv89d7Ebmm6gSc1TfnGT8_nubJ9_R8ibLGMGomIelamII5oqFWlb2ijTucos-Ctm8aDw4VF-cEI_jdnY5-bMfFrl0ia2hrpsDK6R74EbA0-VcvFu-ivColG4ueoraNwmm8hchhldfNzNt1CVC5dyKCIB8wB3ZhYZwfdqPISOuYUrzmjdJK_4pPV8yW7TdI1gtHVK-w_IfR9NhkPX_Q_JLVtvkTuuvuTvLXL30O-cPyKDYQjDNcRkwhDi1LC5sJeTOoQfmIOJCVV9idmbj8nJ_ujbh4PI10iIDLj2eUQrrUXChFZcgTviBbNMFZUWOi2hG3hJC8q1YFoniRGMGRtjuSJRWZ7lVcWzJ2Sjbmr7jIRUQWwIrkpzwWhiM13qNNaFZVylTJkkIIOlsKTxBOJYx-JcthvZmZD1T4lSDUjYAaeOM-Mq5CVKW7rDnt0ok8M0yXMBsyQRkNctAjkqakyCOVWL2Ux-_Pz9BqCvxz3QWw-qGnhfo_zBA_hq5L7qIQc95Klj_r4OuNMDwpA0vdvbSyWS3iTMZKfA8O3dXXwQs9xq2ywAkmDNIAGSDv-BQPLKDELaPCBPnU52Ek7bcsZFFhDe09YOgETi_Tv15KwlFMdyVYLSgLxa6vXf177ScSOn8L1mzxdTuDRccmYlRL0MI02pbBxLWjIrlTKFBGXUvNTUsBz-68c17bgpp_Q8V2e-venKAvaNGn_-X_lvk3suBQTX0XbIxvxiYV9AZDnXu6392CWb70dHX47_AP-aeQo |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELdGJz5eEIyvsMECgu0pWpPYsfOAUIFOLVsLGhuaeDF24myVRlrWVmx_FP8jd3Eamm6gvUxKnvyL41zOd2f7Pgh5FYYsAauYe2kgmh4NlPK0SY0X6kiFBvQVMxgo3OtHnQP68ZAdLpHfs1gYdKucycRCUKfDBPfIt0CNgaYKuHg7-ulh0Sg8XJ1V0LBcsWPOf8GKbfym-wF-7-sg2G7vv-94ZVEBLwFdOPFoprXwmdCKK5DfPGaGqTjTQgcpjJunNKZcC6a17yeCscQ0sb6PyAwPoyzjIfR7gyzTEFYyDbL8rt3_vFeJfpg8sXVyFJ6AlYeN0sUc5Fs5hr2jN-Oc-ltUAnNacNFDszqmXUhpWqjB7Xvkbmm_ui3LcPfJkslXyE1b0fJ8hdzqlWf1D8hGywUB4aL7oguWsTs8NWeD3IULBNAgcVV-hv6iD8nBtRDwEWnkw9w8IS5VYI2CctRcMOqbUKc6aOrYMK4CphLfIRszYsmkTFmOlTNOZHF0HgqZ_5BIVYe4FXBks3RchKwjtaUNL63mtWwFfhQJWJcJh7wsEJgVI0e3myM1HY9l99PXK4C-7NVAmyUoG8J4E1WGOsBXY7atGnKjhjyyucYvA67VgCAEklrz6oyJZCmExrKaMvDtVSs-iH51uRlOAeJjlSIBlHb_gcB0mSEY0ZFDHluerCgcFAWU49AhvMatFQBTl9db8sFxkcIcC2QJSh3yYsbXf4d94ce1LcPXuj2ZjuDWcMuxkWBnM7RtpTLNpqQpM1KpJJbAjJqnmiYsgnd9u6Qfu8iVZWat47K_0dyW-ZU6f_pf-q-T25393q7c7fZ3Vskd64CCu3hrpDE5nZpnYNdO9PNSmrjk-3ULsD_oFLZl |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELfGENNeEIyvsMECgvIUtflw7DwgVLFVK2MDAZsqXoztOFulLS1rK7Y_jf-OuzgJTTfQXiYlT_7FiS_nu7N9H4S8CkOqwSpmXhrwjhcFUnrKpMYLVSxDA_qKGgwU3tuPdw6iDwM6WCK_q1gYdKusZGIhqNORxj3yNqgx0FQB4-2s9Ir4vNV7N_7pYQEpPGitqmlYDtk1F79g9TZ529-CX_06CHrb397veGWBAU-DXpx6UaYU9ylXkkmQ5SyhhsokU1wFKYyBpVESMcWpUr6vOaXadLDWD88MC-MsYyH0e4vcZiH1cYqxQb3Ww2mUWHdH7nFYg9h4XcxG3s4xAB79GucU4aI6mNOHi76a9YHtQnLTQiH27pG7pSXrdi3r3SdLJl8jd2xty4s1srJXnto_IK2uC6LCRUdGF2xkd3Rmzoe5CxeIoqF2ZX6OnqMPycGNkO8RWc5HuXlC3EiCXQpqUjFOI9-EKlVBRyWGMhlQqX2HtCpiCV0mL8caGieiOEQPuchPBVLVIW4NHNt8HZchm0htYQNN6xkuuoEfxxxWaNwhLwsE5sfIkdWO5GwyEf1Ph9cAff3SAL0pQdkIvlfLMugBRo15txrIVgN5ZLOOXwXcaABBHOhG83rFRKIURxNRTx4Ye92KD6KHXW5GM4D4WK-IA6XdfyAwcWYI5nTskMeWJ2sKB0Up5SR0CGtwaw3AJObNlnx4XCQzx1JZPIoc8qLi67-ffenHbVuGb3R7MhvDreAWEyPA4qZo5QppOh0RpdQIKXUigBkVS1WkaQzv-n5FP3a5K8ocW8dlf-O5zfNrdf70v_TfJCsgtsTH_v7uOlm1nii4nbdBlqdnM_MMDNypel6IEpf8uGnZ9Qc6q7k1 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+key+role+for+orexin+in+panic+anxiety&rft.jtitle=Nature+medicine&rft.au=Johnson%2C+Philip+L&rft.au=Truitt%2C+William&rft.au=Fitz%2C+Stephanie+D&rft.au=Minick%2C+Pamela+E&rft.date=2010-01-01&rft.pub=Nature+Publishing+Group&rft.issn=1078-8956&rft.volume=16&rft.issue=1&rft.spage=111&rft_id=info:doi/10.1038%2Fnm.2075&rft.externalDocID=A216681748 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1078-8956&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1078-8956&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1078-8956&client=summon |