Combined effect of genetic polymorphisms of AURKA and environmental factors on oral cancer development in Taiwan

• Published in: PLOS ONE Vol. 12; no. 2; p. e0171583
• Main Authors: Chou, Chia-Hsuan, Chou, Ying-Erh, Chuang, Chun-Yi, Yang, Shun-Fa, Lin, Chiao-Wen
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science (PLoS) 02.02.2017; Public Library of Science
• Subjects: Alcohol use; Analysis; Areca; Areca - adverse effects; Aurora Kinase A; Aurora Kinase A - genetics; Biology and Life Sciences; Breast cancer; Cancer; Carcinoma, Squamous Cell; Carcinoma, Squamous Cell - etiology; Carcinoma, Squamous Cell - genetics; Case-Control Studies; Chewing; Confidence intervals; Disease susceptibility; Ecological risk assessment; Environmental aspects; Environmental factors; Environmental risk; Gene Frequency; Gene Frequency - genetics; Genetic polymorphisms; Genetic Predisposition to Disease; Genetic Predisposition to Disease - genetics; Haplotypes; Health risk assessment; Health risks; Humans; Male; Mastication; Medical research; Medicine; Medicine and Health Sciences; Middle Aged; Mouth cancer; Mouth Neoplasms; Mouth Neoplasms - etiology; Mouth Neoplasms - genetics; Mutation; Oral cancer; Oral squamous cell carcinoma; Patients; Polymerase chain reaction; Polymorphism; Polymorphism, Single Nucleotide; Polymorphism, Single Nucleotide - genetics; Protein-serine/threonine kinase; Q; R; Real-Time Polymerase Chain Reaction; Research Article; Risk analysis; Risk Factors; Risk management; Science; Single-nucleotide polymorphism; Smoking; Smoking - adverse effects; Squamous cell carcinoma; Taiwan; Taiwan - epidemiology; Threonine; Tumorigenesis; Taiwan

Oral squamous cell carcinoma (OSCC) is the sixth and fourth most common cause of cancer death in men worldwide and in Taiwan, respectively. AURKA, which encodes a centrosome-related serine/threonine kinase, is frequently amplified and overexpressed in many human cancers, particularly advanced OSCC....