Identification of Anion Channels Responsible for Fluoride Resistance in Oral Streptococci

• Published in: PLOS ONE Vol. 11; no. 11; p. e0165900
• Main Authors: Men, Xiaochen, Shibata, Yukie, Takeshita, Toru, Yamashita, Yoshihisa
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science (PLoS) 08.11.2016; Public Library of Science
• Subjects: Anion channels; Bacteria; Biofilms; Biology and Life Sciences; Blast resistance; Chloride; Cloning; Coexistence; Complementation; Dentistry; Deoxyribonucleic acid; DNA; Drug Resistance, Bacterial; Drug Resistance, Bacterial - genetics; E coli; Escherichia coli; Fluorides; Fluorides - pharmacology; Genes; Genes, Bacterial; Genes, Bacterial - genetics; Genetic engineering; Genomes; Humans; Ion Channels; Ion Channels - genetics; Ion Channels - physiology; Laboratories; Medicine; Medicine and Health Sciences; Mens health; Metabolism; Mouth; Mouth - microbiology; Oral hygiene; Physical Sciences; Plasmids; Public health; Q; R; Relative abundance; Research and Analysis Methods; Research Article; Science; Streptococcus; Streptococcus - drug effects; Streptococcus - genetics; Streptococcus anginosus; Streptococcus anginosus - drug effects; Streptococcus anginosus - genetics; Streptococcus gordonii; Streptococcus gordonii - drug effects; Streptococcus gordonii - genetics; Streptococcus infections; Streptococcus intermedius; Streptococcus intermedius - drug effects; Streptococcus intermedius - genetics; Streptococcus mitis; Streptococcus mutans; Streptococcus mutans - drug effects; Streptococcus mutans - genetics; Streptococcus oralis; Streptococcus oralis - drug effects; Streptococcus oralis - genetics; Streptococcus salivarius; Streptococcus salivarius - drug effects; Streptococcus salivarius - genetics; Streptococcus sanguinis; Streptococcus sobrinus; Streptococcus sobrinus - drug effects; Streptococcus sobrinus - genetics; Toxicity

Recently, it has been reported that eriC and crcB are involved in bacterial fluoride resistance. However, the fluoride-resistance mechanism in oral streptococci remains unclear. BLAST studies showed that two types of eriCs (eriC1 and eriC2) and two types of crcBs (crcB1 and crcB2) are present across...