Comparison of HIV-1 nef and gag Variations and Host HLA Characteristics as Determinants of Disease Progression among HIV-1 Vertically Infected Kenyan Children

• Published in: PloS one Vol. 10; no. 8; p. e0137140
• Main Authors: Saina, Matilda Chelimo, Bi, Xiuqiong, Lihana, Raphael, Lwembe, Raphael, Ishizaki, Azumi, Panikulam, Annie, Palakudy, Tresa, Musoke, Rachel, Owens, Mary, Songok, Elijah Maritim, Ichimura, Hiroshi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.08.2015; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Adolescent; Adult; Age; AIDS; Alleles; Antigenic determinants; Antigens; Antiretroviral agents; Child; Child, Preschool; Children; Comparative analysis; Development and progression; Disease Progression; Epitopes; Epitopes - genetics; Epitopes - immunology; Female; gag Gene Products, Human Immunodeficiency Virus - genetics; Genes; Genetic aspects; Genetic Variation; Highly active antiretroviral therapy; HIV; HIV infections; HIV Infections - immunology; HIV Infections - transmission; HIV-1 - genetics; HIV-1 - physiology; HLA antigens; HLA Antigens - genetics; HLA Antigens - immunology; HLA Antigens - metabolism; Host-Pathogen Interactions; Human immunodeficiency virus; Humans; Infant; Infections; Infectious Disease Transmission, Vertical; Kenya; Male; Medical research; Mutation; nef Gene Products, Human Immunodeficiency Virus - genetics; Nef protein; Physiological aspects; Plasma; Proteins; Variation; Viral infections; Viruses; Young Adult; Kenya; Japan; Africa

Disease progression varies among HIV-1-infected individuals. The present study aimed to explore possible viral and host factors affecting disease progression in HIV-1-infected children. Since 2000, 102 HIV-1 vertically-infected children have been followed-up in Kenya. Here we studied 29 children (15...