Mouse genomic variation and its effect on phenotypes and gene regulation

• Published in: Nature (London) Vol. 477; no. 7364; pp. 289 - 294
• Main Authors: Keane, Thomas M., Goodstadt, Leo, Danecek, Petr, White, Michael A., Wong, Kim, Yalcin, Binnaz, Heger, Andreas, Agam, Avigail, Slater, Guy, Goodson, Martin, Furlotte, Nicholas A., Eskin, Eleazar, Nellåker, Christoffer, Whitley, Helen, Cleak, James, Janowitz, Deborah, Hernandez-Pliego, Polinka, Edwards, Andrew, Belgard, T. Grant, Oliver, Peter L., McIntyre, Rebecca E., Bhomra, Amarjit, Nicod, Jérôme, Gan, Xiangchao, Yuan, Wei, van der Weyden, Louise, Steward, Charles A., Bala, Sendu, Stalker, Jim, Mott, Richard, Durbin, Richard, Jackson, Ian J., Czechanski, Anne, Guerra-Assunção, José Afonso, Donahue, Leah Rae, Reinholdt, Laura G., Payseur, Bret A., Ponting, Chris P., Birney, Ewan, Flint, Jonathan, Adams, David J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.09.2011; Nature Publishing Group
• Subjects: 631/1647/334/1874/345; 631/208/200; 631/208/726/649; Alleles; Animals; Animals, Laboratory - genetics; Artificial chromosomes; Biological and medical sciences; Classical genetics, quantitative genetics, hybrids; Comparative analysis; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Regulation - genetics; Gene mapping; Genetic aspects; Genetic variation; Genetic Variation - genetics; Genetics; Genetics of eukaryotes. Biological and molecular evolution; Genome - genetics; Genomes; Genomics; Humanities and Social Sciences; Identification and classification; Life Sciences; Mice; Mice - classification; Mice - genetics; Mice, Inbred C57BL - genetics; Mice, Inbred Strains - genetics; multidisciplinary; Phenotype; Phylogeny; Quantitative Trait Loci - genetics; Rodents; Science; Science (multidisciplinary); Statistical analysis; Statistical methods; Vertebrata; United Kingdom; Vertebrata; Phenotype; Regulation(control); Mammalia; Gene; Mouse; Nucleotide sequence; Genomics; Rodentia; Strain

We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more variants than previously known. We use these genomes to explore the phylogenetic history of the laboratory mouse and to examine the functional consequences of allele-specific variation on transcript...