Genome stability of Lyme disease spirochetes: comparative genomics of Borrelia burgdorferi plasmids

• Published in: PloS one Vol. 7; no. 3; p. e33280
• Main Authors: Casjens, Sherwood R, Mongodin, Emmanuel F, Qiu, Wei-Gang, Luft, Benjamin J, Schutzer, Steven E, Gilcrease, Eddie B, Huang, Wai Mun, Vujadinovic, Marija, Aron, John K, Vargas, Levy C, Freeman, Sam, Radune, Diana, Weidman, Janice F, Dimitrov, George I, Khouri, Hoda M, Sosa, Julia E, Halpin, Rebecca A, Dunn, John J, Fraser, Claire M
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.03.2012; Public Library of Science (PLoS)
• Subjects: Analysis; Arthropods; Bacterial Proteins - metabolism; BASIC BIOLOGICAL SCIENCES; Biodiversity; Biological evolution; Biology; Borrelia; Borrelia burgdorferi; Borrelia burgdorferi - genetics; Borrelia burgdorferi - isolation & purification; CHROMOSOMES; Chromosomes, Bacterial - genetics; Comparative analysis; COMPATIBILITY; DISEASES; DNA, Bacterial - metabolism; Epizootics; Evolution; Fines & penalties; gene rearrangement; GENES; Genetic diversity; Genetic research; Genetic Variation; GENETICS; Genome, Bacterial; Genomes; Genomic Instability - genetics; Genomics; Homologous Recombination - genetics; Humans; Laboratories; Lyme disease; Lyme Disease - microbiology; Medicine; Metabolism; Molecular structure; Mutation - genetics; NORTH AMERICA; NUCLEOTIDES; Open Reading Frames - genetics; PATHOGENESIS; Pathology; PLASMIDS; Plasmids - genetics; Population structure; Proteins; Pseudogenes - genetics; Sequence Analysis, DNA; Spirochetes; STABILITY; STRAINS; Strains (organisms); Tandem Repeat Sequences - genetics; TICKS; Trends; Vector-borne diseases; New York; United States > US; Maryland; Utah; Baltimore Maryland

Lyme disease is the most common tick-borne human illness in North America. In order to understand the molecular pathogenesis, natural diversity, population structure and epizootic spread of the North American Lyme agent, Borrelia burgdorferi sensu stricto, a much better understanding of the natural...