Genetic variation of the blood coagulation regulator tissue factor pathway inhibitor and venous thromboembolism among middle‐aged and older adults: A population‐based cohort study

• Published in: Research and practice in thrombosis and haemostasis Vol. 6; no. 7; pp. e12842 - n/a
• Main Authors: Manderstedt, Eric, Lind‐Halldén, Christina, Halldén, Christer, Elf, Johan, Svensson, Peter J., Engström, Gunnar, Melander, Olle, Baras, Aris, Lotta, Luca A., Zöller, Bengt, Abecasis, Goncalo, Cantor, Michael, Coppola, Giovanni, Economides, Aris, Overton, John D., Reid, Jeffrey G., Shuldiner, Alan, Beechert, Christina, Forsythe, Caitlin, Fuller, Erin D., Gu, Zhenhua, Lattari, Michael, Lopez, Alexander, Schleicher, Thomas D., Padilla, Maria Sotiropoulos, Widom, Louis, Wolf, Sarah E., Pradhan, Manasi, Manoochehri, Kia, Ulloa, Ricardo H., Bai, Xiaodong, Balasubramanian, Suganthi, Blumenfeld, Andrew, Boutkov, Boris, Eom, Gisu, Habegger, Lukas, Hawes, Alicia, Khalid, Shareef, Krasheninina, Olga, Lanche, Rouel, Mansfield, Adam J., Maxwell, Evan K., Nafde, Mrunali, O’Keeffe, Sean, Orelus, Max, Panea, Razvan, Polanco, Tommy, Rasool, Ayesha, Salerno, William, Staples, Jeffrey C., Jones, Marcus B., Mighty, Jason, Mitnaul, Lyndon J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2022; Elsevier Limited; John Wiley and Sons Inc; Elsevier
• Subjects: adult; Anticoagulants; Basic Medicine; blood clotting; blood coagulation; Brief Report; Brief Reports; Cardiac and Cardiovascular Systems; Cardiology and Cardiovascular Disease; Clinical Medicine; Cohort analysis; deep vein thrombosis; exosome; female; Gene expression; gene frequency; gene mutation; genetic analysis; genetic screening; genetic variation; Genomes; haplotype; Hematologi; Hematology; human; ICD-10; ICD-9; Kardiologi; Kardiologi och kardiovaskulära sjukdomar; Klinisk medicin; loss of function mutation; major clinical study; male; Medical and Health Sciences; Medical Genetics; Medical Genetics and Genomics (including Gene Therapy); Medicin och hälsovetenskap; Medicinsk genetik; Medicinsk genetik och genomik (Här ingår: Genterapi); Medicinska och farmaceutiska grundvetenskaper; missense mutation; molecular epidemiology; Older people; Population; Population-based studies; principal component analysis; single nucleotide polymorphism; Thromboembolism; thrombophilia; thrombophlebitis; Thrombosis; tissue factor pathway inhibitor; vein thrombosis; Veins & arteries; venous thromboembolism; whole exome sequencing; Sweden; molecular epidemiology; thrombophilia; genetic variation; blood coagulation; venous thromboembolism

Tissue factor is the main initiator of blood coagulation, and tissue factor pathway inhibitor (TFPI) is the primary inhibitor of the initiation of blood coagulation. The genetic variation of TFPI and the relation to venous thromboembolism (VTE), that is, venous thrombosis and pulmonary embolism, rem...