Yip1A, a Novel Host Factor for the Activation of the IRE1 Pathway of the Unfolded Protein Response during Brucella Infection

• Published in: PLoS pathogens Vol. 11; no. 3; p. e1004747
• Main Authors: Taguchi, Yuki, Imaoka, Koichi, Kataoka, Michiyo, Uda, Akihiko, Nakatsu, Daiki, Horii-Okazaki, Sakuya, Kunishige, Rina, Kano, Fumi, Murata, Masayuki
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.03.2015; Public Library of Science (PLoS)
• Subjects: Autophagy; Bacterial infections; Bacterial proteins; Biosynthesis; Blotting, Western; Brucella; Brucella abortus - physiology; Brucellosis; Brucellosis - immunology; Brucellosis - pathology; Endoplasmic Reticulum - metabolism; Endoplasmic Reticulum - microbiology; Endoplasmic Reticulum - pathology; Endoribonucleases - immunology; Endoribonucleases - metabolism; Experiments; Health aspects; HeLa Cells; Host-bacteria relationships; Host-Parasite Interactions - physiology; Humans; Identification and classification; Infections; Kinases; Microscopy; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Pathogenesis; Protein folding; Protein-Serine-Threonine Kinases - immunology; Protein-Serine-Threonine Kinases - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Software; Transfection; Unfolded Protein Response - immunology; Vaccines; Vacuoles - metabolism; Vacuoles - microbiology; Vacuoles - pathology; Vesicular Transport Proteins - immunology; Vesicular Transport Proteins - metabolism; Virus Replication - physiology

Brucella species replicate within host cells in the form of endoplasmic reticulum (ER)-derived vacuoles. The mechanisms by which the bacteria are sequestered into such vacuoles and obtain a continuous membrane supply for their replication remain to be elucidated. In the present study, we provided se...