Dynamics of Cell Generation and Turnover in the Human Heart
The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers o...
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| Published in | Cell Vol. 161; no. 7; pp. 1566 - 1575 |
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| Main Authors | , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
18.06.2015
Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived 14C revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart.
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•The number of cardiomyocytes remains constant during the human lifespan•Endothelial and mesenchymal cells increase into adulthood and show high turnover•Cardiomyocyte turnover decreases exponentially with age and is <1% per year in adults•The cardiomyocyte turnover rate is equal in the main subdivisions of the human heart
A comprehensive analysis of cell generation and turnover in the human heart demonstrates that cardiomyocyte numbers are constant throughout the human lifespan, with a low turnover rate. Endothelial and mesenchymal cells are exchanged at a high rate, and their numbers increase into adulthood. |
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| AbstractList | The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived (14)C revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart. The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived (14)C revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart. The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived 14C revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart. The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived C-14 revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart. The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived (14)C revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart. VIDEO ABSTRACT. The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived 14C revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart. [Display omitted] [Display omitted] •The number of cardiomyocytes remains constant during the human lifespan•Endothelial and mesenchymal cells increase into adulthood and show high turnover•Cardiomyocyte turnover decreases exponentially with age and is <1% per year in adults•The cardiomyocyte turnover rate is equal in the main subdivisions of the human heart A comprehensive analysis of cell generation and turnover in the human heart demonstrates that cardiomyocyte numbers are constant throughout the human lifespan, with a low turnover rate. Endothelial and mesenchymal cells are exchanged at a high rate, and their numbers increase into adulthood. |
| Author | Jashari, Ramadan Szewczykowska, Mirosława Possnert, Göran Jackowska, Teresa Malm, Torsten Sjostrom, Staffan L. Jovinge, Stefan Salehpour, Mehran Alkass, Kanar Frisén, Jonas dos Remedios, Cris Felker, Anastasia Bernard, Samuel Bergmann, Olaf Zdunek, Sofia Nyengaard, Jens R. Druid, Henrik Andrä, Michaela |
| Author_xml | – sequence: 1 givenname: Olaf surname: Bergmann fullname: Bergmann, Olaf email: olaf.bergmann@ki.se organization: Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden – sequence: 2 givenname: Sofia surname: Zdunek fullname: Zdunek, Sofia organization: Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden – sequence: 3 givenname: Anastasia surname: Felker fullname: Felker, Anastasia organization: Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden – sequence: 4 givenname: Mehran surname: Salehpour fullname: Salehpour, Mehran organization: Division of Ion Physics, Department of Physics and Astronomy, Uppsala University, 751 20 Uppsala, Sweden – sequence: 5 givenname: Kanar surname: Alkass fullname: Alkass, Kanar organization: Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden – sequence: 6 givenname: Samuel surname: Bernard fullname: Bernard, Samuel organization: Department of Mathematics, Institut Camille Jordan, Université de Lyon, 69622 Villeurbanne Cedex, France – sequence: 7 givenname: Staffan L. surname: Sjostrom fullname: Sjostrom, Staffan L. organization: Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden – sequence: 8 givenname: Mirosława surname: Szewczykowska fullname: Szewczykowska, Mirosława organization: Department of Pediatrics, Bielanski Hospital, 01-809 Warsaw, Poland – sequence: 9 givenname: Teresa surname: Jackowska fullname: Jackowska, Teresa organization: Department of Pediatrics, Bielanski Hospital, 01-809 Warsaw, Poland – sequence: 10 givenname: Cris surname: dos Remedios fullname: dos Remedios, Cris organization: Discipline of Anatomy, Bosch Institute, University of Sydney, Sydney, NSW 2006, Australia – sequence: 11 givenname: Torsten surname: Malm fullname: Malm, Torsten organization: Department of Paediatric Cardiac Surgery, Skåne University Hospital, 221 85 Lund, Sweden – sequence: 12 givenname: Michaela surname: Andrä fullname: Andrä, Michaela organization: Klinikum Klagenfurt & Section for Surgical Research, Department of Cardiothoracic and Vascular Surgery, Medical University Graz, 9020 Graz, Austria – sequence: 13 givenname: Ramadan surname: Jashari fullname: Jashari, Ramadan organization: European Homograft Bank, 1120 Brussels, Belgium – sequence: 14 givenname: Jens R. surname: Nyengaard fullname: Nyengaard, Jens R. organization: Stereology and Electron Microscopy Laboratory, Centre for Stochastic Geometry and Advance Bioimaging, Aarhus University, 8000 Aarhus, Denmark – sequence: 15 givenname: Göran surname: Possnert fullname: Possnert, Göran organization: Division of Ion Physics, Department of Physics and Astronomy, Uppsala University, 751 20 Uppsala, Sweden – sequence: 16 givenname: Stefan surname: Jovinge fullname: Jovinge, Stefan organization: Spectrum Health Frederik Meijer Heart & Vascular Institute, Grand Rapids, MI 49503, USA – sequence: 17 givenname: Henrik surname: Druid fullname: Druid, Henrik organization: Department of Forensic Medicine, Karolinska Institute, 171 77 Stockholm, Sweden – sequence: 18 givenname: Jonas surname: Frisén fullname: Frisén, Jonas email: jonas.frisen@ki.se organization: Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26073943$$D View this record in MEDLINE/PubMed https://hal.science/hal-01225091$$DView record in HAL https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-258335$$DView record from Swedish Publication Index https://lup.lub.lu.se/record/7486280$$DView record from Swedish Publication Index http://kipublications.ki.se/Default.aspx?queryparsed=id:131468552$$DView record from Swedish Publication Index |
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| Title | Dynamics of Cell Generation and Turnover in the Human Heart |
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