Nanog safeguards pluripotency and mediates germline development

• Published in: Nature Vol. 450; no. 7173; pp. 1230 - 1234
• Main Authors: Chambers, Ian, Silva, Jose, Colby, Douglas, Nichols, Jennifer, Nijmeijer, Bianca, Robertson, Morag, Vrana, Jan, Jones, Ken, Grotewold, Lars, Smith, Austin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.12.2007; Nature Publishing; Nature Publishing Group
• Subjects: Alleles; Animals; Biological and medical sciences; Cell Differentiation; Cell differentiation, maturation, development, hematopoiesis; Cell Division; Cell physiology; Cells, Cultured; Cellular biology; Chimera - metabolism; DNA-Binding Proteins - deficiency; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Embryo, Mammalian - cytology; Embryonic Stem Cells - cytology; Embryonic Stem Cells - metabolism; Embryos; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Regulation; Germ Cells - cytology; Germ Cells - metabolism; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Humanities and Social Sciences; letter; Mammals; Mice; Molecular and cellular biology; multidisciplinary; Nanog Homeobox Protein; Pluripotent Stem Cells - cytology; Pluripotent Stem Cells - metabolism; Proteins; Rodents; Science; Science (multidisciplinary); Stem cells; Vertebrata; Mammalia; Mouse; Germ line; Rodentia; Development; Transcription factor

Nanog is a divergent homeodomain protein found in mammalian pluripotent cells and developing germ cells. Deletion of Nanog causes early embryonic lethality, whereas constitutive expression enables autonomous self-renewal of embryonic stem cells. Nanog is accordingly considered a core element of the...