Tissue factor and thrombosis: The clot starts here

• Published in: Thrombosis and haemostasis Vol. 104; no. 3; p. 432
• Main Authors: Owens, 3rd, A Phillip, Mackman, Nigel
• Format: Journal Article
• Language: English
• Published: Germany 01.09.2010
• Subjects: Animals; Arterial Occlusive Diseases - blood; Blood Coagulation - drug effects; Disease Models, Animal; Disseminated Intravascular Coagulation - blood; Fibrinolytic Agents - pharmacology; Humans; Microcirculation; Thromboplastin - metabolism; Thrombosis - blood; Thrombosis - drug therapy; Thrombosis - physiopathology; Venous Thrombosis - blood

Thrombosis, or complications from thrombosis, currently occupies the top three positions in the cardiovascular causes of morbidity and mortality in the developed world. There are a limited number of safe and effective drugs to prevent and treat thrombosis. Animal models of thrombosis are necessary t...