Tissue factor and thrombosis: The clot starts here

Thrombosis, or complications from thrombosis, currently occupies the top three positions in the cardiovascular causes of morbidity and mortality in the developed world. There are a limited number of safe and effective drugs to prevent and treat thrombosis. Animal models of thrombosis are necessary t...

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Published inThrombosis and haemostasis Vol. 104; no. 3; p. 432
Main Authors Owens, 3rd, A Phillip, Mackman, Nigel
Format Journal Article
LanguageEnglish
Published Germany 01.09.2010
Subjects
Animals
Arterial Occlusive Diseases - blood
Blood Coagulation - drug effects
Disease Models, Animal
Disseminated Intravascular Coagulation - blood
Fibrinolytic Agents - pharmacology
Humans
Microcirculation
Thromboplastin - metabolism
Thrombosis - blood
Thrombosis - drug therapy
Thrombosis - physiopathology
Venous Thrombosis - blood
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Abstract Thrombosis, or complications from thrombosis, currently occupies the top three positions in the cardiovascular causes of morbidity and mortality in the developed world. There are a limited number of safe and effective drugs to prevent and treat thrombosis. Animal models of thrombosis are necessary to better understand the complex components and interactions involved in the formation of a clot. Tissue factor (TF) is required for the initiation of blood coagulation and likely plays a key role in both arterial and venous thrombosis. Understanding the role of TF in thrombosis may permit the development of new antithrombotic drugs. This review will focus on the role of TF in in vivo models of thrombosis.
AbstractList Thrombosis, or complications from thrombosis, currently occupies the top three positions in the cardiovascular causes of morbidity and mortality in the developed world. There are a limited number of safe and effective drugs to prevent and treat thrombosis. Animal models of thrombosis are necessary to better understand the complex components and interactions involved in the formation of a clot. Tissue factor (TF) is required for the initiation of blood coagulation and likely plays a key role in both arterial and venous thrombosis. Understanding the role of TF in thrombosis may permit the development of new antithrombotic drugs. This review will focus on the role of TF in in vivo models of thrombosis.
Author Owens, 3rd, A Phillip
Mackman, Nigel
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SubjectTerms Animals
Arterial Occlusive Diseases - blood
Blood Coagulation - drug effects
Disease Models, Animal
Disseminated Intravascular Coagulation - blood
Fibrinolytic Agents - pharmacology
Humans
Microcirculation
Thromboplastin - metabolism
Thrombosis - blood
Thrombosis - drug therapy
Thrombosis - physiopathology
Venous Thrombosis - blood
Title Tissue factor and thrombosis: The clot starts here
URI https://www.ncbi.nlm.nih.gov/pubmed/20539911
Volume 104
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