Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram

• Published in: Thrombosis and haemostasis Vol. 102; no. 5; p. 936
• Main Authors: Machlus, Kellie R, Colby, Emily A, Wu, Jogin R, Koch, Gary G, Key, Nigel S, Wolberg, Alisa S
• Format: Journal Article
• Language: English
• Published: Germany 01.11.2009
• Subjects: Adult; Automation; Blood Coagulation Factors - physiology; Blood Coagulation Tests; Calibration; Coumarins - analysis; Female; Fluorometry - instrumentation; Fluorometry - methods; Humans; Male; Middle Aged; Oligopeptides - analysis; Plasma; Platelet-Rich Plasma; Thrombin - biosynthesis; Thrombomodulin - physiology; Thromboplastin - physiology; Time Factors; Young Adult

Elevated procoagulant levels have been correlated with increased thrombin generation in vitro and with increased venous thromboembolism (VTE) risk in epidemiological studies. Thrombin generation tests are increasingly being employed as a high throughput method to provide a global measure of procoagu...