Hypoxia-induced changes in the bioactivity of cytotrophoblast-derived exosomes

• Published in: PloS one Vol. 8; no. 11; p. e79636
• Main Authors: Salomon, Carlos, Kobayashi, Miharu, Ashman, Keith, Sobrevia, Luis, Mitchell, Murray D, Rice, Gregory E
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.11.2013; Public Library of Science (PLoS)
• Subjects: Arterioles; Biological activity; Cell interactions; Cell migration; Cell Movement; Cell Proliferation; Centrifugation; Cloning; Communication; Computed tomography; Conditioning; Decidua; Deoxyribonuclease; Differential media; Exosomes; Exosomes - metabolism; Female; Fetuses; Humans; Hypotheses; Hypoxia; Hypoxia - metabolism; Laboratories; Myometrium; Oxidative stress; Oxygen; Oxygen - metabolism; Oxygen tension; Perfusion; Phenotypes; Placenta; Preeclampsia; Pregnancy; Protein Interaction Maps; Proteins; Proteome; Proteomics; Rodents; Signal Transduction; Stem cells; Tension; Trophoblasts; Trophoblasts - metabolism; Trypsin; Australia; Chile; United States > US

Migration of extravillous trophoblasts (EVT) into decidua and myometrium is a critical process in the conversion of maternal spiral arterioles and establishing placenta perfusion. EVT migration is affected by cell-to-cell communication and oxygen tension. While the release of exosomes from placental...