Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial

• Published in: Stem cell research & therapy Vol. 9; no. 1; pp. 213 - 15
• Main Authors: Gjerde, Cecilie, Mustafa, Kamal, Hellem, Sølve, Rojewski, Markus, Gjengedal, Harald, Yassin, Mohammed Ahmed, Feng, Xin, Skaale, Siren, Berge, Trond, Rosen, Annika, Shi, Xie-Qi, Ahmed, Aymen B., Gjertsen, Bjørn Tore, Schrezenmeier, Hubert, Layrolle, Pierre
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.08.2018; BioMed Central; BMC
• Subjects: Adherent cells; Adolescent; Adult; Aged; Aged, 80 and over; Alveolar Bone Loss - surgery; Alveolar ridge augmentation; Analysis; Autografts; Biphasic calcium phosphate; Bone growth; Bone healing; Bone implants; Bone marrow; Bone Marrow Cells - cytology; Bone regeneration; Bone Regeneration - physiology; Bone resorption; Bone tissue engineering; Bone Transplantation - methods; Calcium phosphates; Cell culture; Cell- and Tissue-Based Therapy - methods; Clinical trials; Complications; Defects; Dental Implants; Dental prosthetics; Dental restorative materials; Female; Gene expression; Health aspects; Humans; Hydroxyapatites - chemistry; Iliac crest; Male; Mandible; Maxillofacial; Mesenchymal stem cells; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - physiology; Mesenchyme; Middle Aged; Osteogenesis; Patient satisfaction; Patients; Regeneration; Skin & tissue grafts; Stem cells; Stromal cells; Systematic review; Tissue Engineering - methods; Tomography; Wound Healing - physiology; Young Adult; Biphasic calcium phosphate; Alveolar ridge augmentation; Bone tissue engineering; Dental implants; Bone regeneration; Mesenchymal stem cells

Autologous grafting, despite some disadvantages, is still considered the gold standard for reconstruction of maxillofacial bone defects. The aim of this study was to evaluate bone regeneration using bone marrow-derived mesenchymal stromal cells (MSCs) in a clinical trial, a less invasive approach th...