Lubiprostone improves intestinal permeability in humans, a novel therapy for the leaky gut: A prospective randomized pilot study in healthy volunteers - Kato, Takayuki; Honda, Yasushi; Kurita, Yusuke; Iwasaki, Akito; Sato, Takamitsu; Kessoku, Takaomi; Uchiyama, Shiori; Ogawa, Yuji; Ohkubo, Hidenori; Higurashi, Takuma; Yamanaka, Takeharu; Usuda, Haruki; et al. (PloS one, 2017)
Keywords: Adult; Age; Allergies; Analysis; Animal models; Anti-inflammatory agents; Antibiotics; Antibodies; Aspirin; Assaying; Attention; Autografts; Biology and Life Sciences; Blood; Bone marrow; Bone marrow transplantation; Care and treatment; Cerebral infarction; Chemiluminescence; Chloride Channel Agonists - pharmacology; Chloride Channel Agonists - therapeutic use; Chromatography, High Pressure Liquid; Circulation; Complications; Complications and side effects; Computer programs; Crohn's disease; Crohns disease; Diabetes mellitus; Diclofenac - pharmacology; Diclofenac - therapeutic use; Digestive tract; Diseases; Dosage and administration; Drug Administration Schedule; Drug therapy; Drugs; Endotoxins; Endotoxins - blood; Gastroenterology; Gastrointestinal diseases; Gastrointestinal system; Gastrointestinal tract; Healthy Volunteers; Hepatology; Humans; Immune system; Inhibition; Intestinal Mucosa - metabolism; Intestine; Intestines - drug effects; Irritable Bowel Syndrome - drug therapy; Kidneys; Lactulose - urine; Liver; Liver diseases; Lubiprostone; Lubiprostone - pharmacology; Lubiprostone - therapeutic use; Male; Mannitol - urine; Mass Spectrometry; Medical research; Medicine; Medicine and Health Sciences; Membrane permeability; Mental disorders; Microorganisms; Middle Aged; Mucosa; Myocardial infarction; Neurodegenerative diseases; Nonsteroidal anti-inflammatory drugs; Nutrients; Organs; Pathogens; Permeability; Permeability - drug effects; Pharmacology; Physical Sciences; Pilot Projects; Prospective Studies; Small intestine; Stomach; Tight junctions; Young Adult; Japan