Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence

• Published in: Nature (London) Vol. 553; no. 7688; pp. 351 - 355
• Main Authors: Sulli, Gabriele, Rommel, Amy, Wang, Xiaojie, Kolar, Matthew J., Puca, Francesca, Saghatelian, Alan, Plikus, Maksim V., Verma, Inder M., Panda, Satchidananda
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.01.2018; Nature Publishing Group
• Subjects: 13/1; 45/77; 631/67/1059; 631/80/105; 631/80/509; 64/60; 82/51; 82/80; Aging (Biology); Agonists (Biochemistry); Animals; Anticancer properties; Antitumor activity; Antitumor agents; Apoptosis; Apoptosis - drug effects; Autophagy; Autophagy (Cytology); Autophagy - drug effects; Binding proteins; Biocompatibility; Brain cancer; Cancer; Cancer cells; Cancer therapies; Cancer treatment; Cell aging; Cell cycle; Cell Line, Tumor; Cell proliferation; Cell receptors; Cell Survival - drug effects; Circadian Clocks - genetics; Circadian Clocks - physiology; Circadian rhythm; Circadian rhythms; Cytotoxicity; Deoxyribonucleic acid; DNA; DNA damage; Enzymes; Fatty acids; Female; Gene expression; Genetic aspects; Genomes; Glioblastoma; Glioblastoma - drug therapy; Glioblastoma - pathology; Growth; GTP Phosphohydrolases - genetics; GTP Phosphohydrolases - metabolism; Health aspects; Humanities and Social Sciences; Humans; Hypoxia; letter; Lipogenesis; Lipogenesis - drug effects; Male; Membrane Proteins - genetics; Membrane Proteins - metabolism; Metabolism; Metabolites; Methods; Mice, Inbred C57BL; multidisciplinary; Neoplasia; Neoplasms; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - pathology; Nevus - drug therapy; Nevus - pathology; Nuclear Receptor Subfamily 1, Group D, Member 1 - agonists; Nuclear Receptor Subfamily 1, Group D, Member 1 - metabolism; Nuclear receptors; Oncogenes; Oncogenes - genetics; Oxidative stress; p53 Protein; Phagocytosis; Pharmacology; Pyrrolidines - pharmacology; Receptors; Regulators; Science; Senescence; Signal Transduction - drug effects; Stem cells; Testing; Thiophenes - pharmacology; Toxicity; Tumors; United States

REV-ERBs, nuclear hormone receptors that regulate transcription as part of the circadian clock cell machinery, inhibit autophagy and lipogenesis in premalignant and malignant cells and impair tumour growth in vivo . Tumours restrained by REV-ERBs The circadian clock regulates many of the physiologic...