Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence - Sulli, Gabriele; Rommel, Amy; Wang, Xiaojie; Kolar, Matthew J.; Puca, Francesca; Saghatelian, Alan; Plikus, Maksim V.; Verma, Inder M.; Panda, Satchidananda (Nature (London), 2018)
Keywords: 13/1; 45/77; 631/67/1059; 631/80/105; 631/80/509; 64/60; 82/51; 82/80; Aging (Biology); Agonists (Biochemistry); Animals; Anticancer properties; Antitumor activity; Antitumor agents; Apoptosis; Apoptosis - drug effects; Autophagy; Autophagy (Cytology); Autophagy - drug effects; Binding proteins; Biocompatibility; Brain cancer; Cancer; Cancer cells; Cancer therapies; Cancer treatment; Cell aging; Cell cycle; Cell Line, Tumor; Cell proliferation; Cell receptors; Cell Survival - drug effects; Circadian Clocks - genetics; Circadian Clocks - physiology; Circadian rhythm; Circadian rhythms; Cytotoxicity; Deoxyribonucleic acid; DNA; DNA damage; Enzymes; Fatty acids; Female; Gene expression; Genetic aspects; Genomes; Glioblastoma; Glioblastoma - drug therapy; Glioblastoma - pathology; Growth; GTP Phosphohydrolases - genetics; GTP Phosphohydrolases - metabolism; Health aspects; Humanities and Social Sciences; Humans; Hypoxia; letter; Lipogenesis; Lipogenesis - drug effects; Male; Membrane Proteins - genetics; Membrane Proteins - metabolism; Metabolism; Metabolites; Methods; Mice, Inbred C57BL; multidisciplinary; Neoplasia; Neoplasms; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - pathology; Nevus - drug therapy; Nevus - pathology; Nuclear Receptor Subfamily 1, Group D, Member 1 - agonists; Nuclear Receptor Subfamily 1, Group D, Member 1 - metabolism; Nuclear receptors; Oncogenes; Oncogenes - genetics; Oxidative stress; p53 Protein; Phagocytosis; Pharmacology; Pyrrolidines - pharmacology; Receptors; Regulators; Science; Senescence; Signal Transduction - drug effects; Stem cells; Testing; Thiophenes - pharmacology; Toxicity; Tumors; United States