Human Leukocyte Antigen Class II Haplotypes Affect Clinical Characteristics and Progression of Type 1 Autoimmune Hepatitis in Japan

• Published in: PloS one Vol. 9; no. 6; p. e100565
• Main Authors: Umemura, Takeji, Katsuyama, Yoshihiko, Yoshizawa, Kaname, Kimura, Takefumi, Joshita, Satoru, Komatsu, Michiharu, Matsumoto, Akihiro, Tanaka, Eiji, Ota, Masao
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.06.2014; Public Library of Science (PLoS)
• Subjects: Aged; Alleles; Amino acids; Antigens; Autoimmune diseases; Chronic active hepatitis; Comparative analysis; Development and progression; Diabetes; Disease Progression; Drb1 protein; Female; Follow-Up Studies; Gastroenterology; Genetic Predisposition to Disease; Haplotypes; Haplotypes - genetics; Hepatitis; Hepatitis, Autoimmune - epidemiology; Hepatitis, Autoimmune - genetics; Hepatitis, Autoimmune - immunology; Hepatocellular carcinoma; Hepatology; Histocompatibility antigen HLA; Histocompatibility Antigens Class I - chemistry; Histocompatibility Antigens Class I - genetics; Histocompatibility Antigens Class II - chemistry; Histocompatibility Antigens Class II - genetics; HLA antigens; Humans; Immunoglobulin G; Japan - epidemiology; Legal medicine; Leukocytes; Ligands; Liver cancer; Liver cirrhosis; Liver diseases; Lupus; Male; Medical prognosis; Medicine; Medicine and Health Sciences; Middle Aged; Muscles; Patients; Peptides; Prognosis; Protein Conformation; Smooth muscle; Studies; Japan

Although we earlier demonstrated that the human leukocyte antigen (HLA) DRB1*04:05 allele was associated with susceptibility to autoimmune hepatitis (AIH) in Japan, the precise relationship of HLA haplotype and the role of amino acid alignment with disease susceptibility and progression has not been...