Dysfunction of the blood-brain barrier in postoperative delirium patients, referring to the axonal damage biomarker phosphorylated neurofilament heavy subunit

• Published in: PloS one Vol. 14; no. 10; p. e0222721
• Main Authors: Mietani, Kazuhito, Sumitani, Masahiko, Ogata, Toru, Shimojo, Nobutake, Inoue, Reo, Abe, Hiroaki, Kawamura, Gaku, Yamada, Yoshitsugu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.10.2019; Public Library of Science (PLoS)
• Subjects: Adhesion; Adhesion tests; Aged; Analysis; Anesthesiology; Atrophy; Axons - metabolism; Axons - pathology; Bioindicators; Biological markers; Biology and Life Sciences; Biomarkers; Biomarkers - blood; Blood platelets; Blood-brain barrier; Blood-Brain Barrier - metabolism; Blood-Brain Barrier - physiopathology; Brain damage; Care and treatment; CD31 antigen; Cell adhesion; Cell adhesion & migration; Cell adhesion molecules; Central nervous system; Central Nervous System - metabolism; Central Nervous System - physiopathology; Central Nervous System - surgery; Cognitive ability; Cytokines; Delirium; Delirium - blood; Delirium - etiology; Delirium - physiopathology; Disease; Disease Progression; Disruption; E-selectin; E-Selectin - blood; Endothelial cells; Endothelium; Female; Hospital costs; Humans; Independent variables; Inflammation; Intensive care; Intercellular adhesion molecule 1; Intercellular Adhesion Molecule-1 - blood; Interleukin; Interleukin 1; Interleukin 6; Interleukins; Ischemia; Male; Medicine and Health Sciences; Mental disorders; Middle Aged; Multiple regression analysis; Necrosis; Neurofilament Proteins - blood; P-selectin; P-Selectin - blood; Pain; Palliative care; Patients; Physical Sciences; Platelet Endothelial Cell Adhesion Molecule-1 - blood; Postoperative Complications - blood; Postoperative Complications - pathology; Proteins; Regression analysis; Research and Analysis Methods; Sepsis; Serum levels; Spinal cord; Surgery; Systematic review; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Tumors; Vascular cell adhesion molecule 1; Vascular Cell Adhesion Molecule-1 - blood; Japan

Delirium is the most common postoperative complication of the central nervous system (CNS) that can trigger long-term cognitive impairment. Its underlying mechanism is not fully understood, but the dysfunction of the blood-brain barrier (BBB) has been implicated. The serum levels of the axonal damag...