Beneficial effect of insulin treatment on islet transplantation outcomes in Akita mice

• Published in: PloS one Vol. 9; no. 4; p. e95451
• Main Authors: Kikawa, Kazuhide, Sakano, Daisuke, Shiraki, Nobuaki, Tsuyama, Tomonori, Kume, Kazuhiko, Endo, Fumio, Kume, Shoen
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2014; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Apoptosis; Biology; Biology and Life Sciences; Blood; Blood glucose; Blood Glucose - drug effects; Blood sugar; Cell culture; Chemotaxis; Controlled release; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - surgery; Diabetes therapy; Disease Models, Animal; Drug therapy; Embryology; Gene expression; Glucose; Glucose metabolism; Glucose tolerance; Graduate studies; Grafting; Grafts; Health aspects; Hyperglycemia; Immune response; Immune system; Immunological tolerance; Inflammation; Inflammatory response; Insulin; Insulin - therapeutic use; Insulin resistance; Islet cells; Islets of Langerhans Transplantation; Laboratories; Male; Medicine and Health Sciences; Mice; Missense mutation; Mutation; Pancreas; Pancreatic islet transplantation; Patient outcomes; Pediatrics; Research and Analysis Methods; Rodents; Stem cells; Substance abuse treatment; Surgical implants; Survival; Transplantation; Transplants; Transplants & implants; Tumor necrosis factor-TNF; Type 1 diabetes; Japan

Islet transplantation is a promising potential therapy for patients with type 1 diabetes. The outcome of islet transplantation depends on the transplantation of a sufficient amount of β-cell mass. However, the initial loss of islets after transplantation is problematic. We hypothesized the hyperglyc...