A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

• Published in: Nature (London) Vol. 569; no. 7758; pp. 718 - 722
• Main Authors: Zhao, Baoyu, Du, Fenglei, Xu, Pengbiao, Shu, Chang, Sankaran, Banumathi, Bell, Samantha L., Liu, Mengmeng, Lei, Yuanjiu, Gao, Xinsheng, Fu, Xiaofeng, Zhu, Fanxiu, Liu, Yang, Laganowsky, Arthur, Zheng, Xueyun, Ji, Jun-Yuan, West, A. Phillip, Watson, Robert O., Li, Pingwei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2019; Nature Publishing Group
• Subjects: 14/19; 631/250/262; 631/535/1258; 631/535/1266; 82/1; 82/103; 82/16; 82/29; 82/58; 82/80; 82/83; Amino Acid Motifs; Analysis; Antagonists; Autoimmune diseases; BASIC BIOLOGICAL SCIENCES; Chemical synthesis; Conserved Sequence; Crystallography, X-Ray; Cyclic GMP; EF hand proteins; Enzyme Activation; HEK293 Cells; Humanities and Social Sciences; Humans; Hydrogen bonds; Immune response; Influence; Interferon; Interferon regulatory factor 3; Interferon-beta - metabolism; Letter; Membrane Proteins - chemistry; Membrane Proteins - genetics; Membrane Proteins - metabolism; Models, Molecular; multidisciplinary; Mutation; Nucleic acids; Nucleotides, Cyclic - metabolism; Oligomerization; Peptides; Phosphorylation; Protein Binding; Protein kinases; Protein Serine-Threonine Kinases - metabolism; Science; Science (multidisciplinary); Signal Transduction; β-Interferon

Nucleic acids from bacteria or viruses induce potent immune responses in infected cells 1 – 4 . The detection of pathogen-derived nucleic acids is a central strategy by which the host senses infection and initiates protective immune responses 5 , 6 . Cyclic GMP-AMP synthase (cGAS) is a double-strand...