Internalization and recycling to serotonin-containing granules of the 80K intégral membrane protein exposed on the surface of secreting rat basophilie leukaemia cells
ABSTRACT The 80K (80x103Mr) integra! membrane protein, first described in the secretory granules of rat basophilie leukaemia (RBL) cells, is also localized to lysosomes in these cells. The protein displays the same distribution in natural killer lymphocytes (RNK-7), wherein it codistributes with cyt...
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| Published in | Journal of cell science Vol. 92; no. 4; pp. 701 - 712 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
01.04.1989
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| Online Access | Get full text |
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| Abstract | ABSTRACT
The 80K (80x103Mr) integra! membrane protein, first described in the secretory granules of rat basophilie leukaemia (RBL) cells, is also localized to lysosomes in these cells. The protein displays the same distribution in natural killer lymphocytes (RNK-7), wherein it codistributes with cytolysin in secretory granules. In contrast, the protein is absent from the endocrine and exocrine secretory granules of rat pancreatic acinar and pituitary cells, respectively, where it is confined to lysosomes. The protein colocalizes with lysosomal intégral membrane proteins in ail the cells studied, indicating that is largely restricted to secretory granules with lysosomal properties (LSG) and lysosomes. The protein expressed on the surface of secreting RBL cells is internalized by endocytosis via coated pits, and found in coated vesicles, endosomes, multivesicular bodies and Golgi System, before being recycled to LSG and partly delivered to lysosomes. The recycled protein is re-expressed on the surface of cells stimulated to secrete a second time. |
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| AbstractList | ABSTRACT
The 80K (80x103Mr) integra! membrane protein, first described in the secretory granules of rat basophilie leukaemia (RBL) cells, is also localized to lysosomes in these cells. The protein displays the same distribution in natural killer lymphocytes (RNK-7), wherein it codistributes with cytolysin in secretory granules. In contrast, the protein is absent from the endocrine and exocrine secretory granules of rat pancreatic acinar and pituitary cells, respectively, where it is confined to lysosomes. The protein colocalizes with lysosomal intégral membrane proteins in ail the cells studied, indicating that is largely restricted to secretory granules with lysosomal properties (LSG) and lysosomes. The protein expressed on the surface of secreting RBL cells is internalized by endocytosis via coated pits, and found in coated vesicles, endosomes, multivesicular bodies and Golgi System, before being recycled to LSG and partly delivered to lysosomes. The recycled protein is re-expressed on the surface of cells stimulated to secrete a second time. |
| Author | Yuan, Lydia Bonifacino, Juan S. Sandoval, Ignacio V. |
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| Cites_doi | 10.1073/pnas.83.9.2899 10.1083/jcb.97.4.1303 10.1084/jem.152.1.1 10.1177/22.12.1077 10.1083/jcb.103.1.277 10.1016/S0021-9258(18)66630-X 10.1146/annurev.iy.03.040185.000335 10.1002/aja.1001580409 10.1083/jcb.105.1.215 10.4049/jimmunol.124.6.2728 10.1177/14.4.291 10.1016/0165-5728(88)90120-8 10.1016/S0091-679X(08)61512-5 10.1083/jcb.77.3.R35 10.1073/pnas.80.5.1300 10.1083/jcb.102.1.77 10.1177/29.12.7033368 10.1073/pnas.75.7.3327 10.1002/ana.410070414 10.1083/jcb.102.2.510 10.1083/jcb.103.1.265 10.1073/pnas.81.16.5135 10.1083/jcb.100.3.826 10.1016/0092-8674(82)90219-7 10.1073/pnas.82.4.1146 10.1016/S0021-9258(17)33677-3 10.1083/jcb.98.5.1817 10.1016/S0091-679X(08)61511-3 10.1083/jcb.102.2.516 |
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| References | Bonifacino (2023071212451521900_JOCES_92_4_701C2) 1985; 82 Herzog (2023071212451521900_JOCES_92_4_701C15) 1979; 19 Liu (2023071212451521900_JOCES_92_4_701C17) 1980; 124 Brown (2023071212451521900_JOCES_92_4_701C4) 1984; 81 Barriocanal (2023071212451521900_JOCES_92_4_701C1) 1986; 261 Farquhar (2023071212451521900_JOCES_92_4_701C8) 1981; 23 Dvorak (2023071212451521900_JOCES_92_4_701C6) 1972; 26 Farquhar (2023071212451521900_JOCES_92_4_701C7) 1978; 78 Siraganian (2023071212451521900_JOCES_92_4_701C26) 1984 Woods (2023071212451521900_JOCES_92_4_701C33) 1986; 103 Bonifacino (2023071212451521900_JOCES_92_4_701C3) 1986; 102 Gaspar (2023071212451521900_JOCES_92_4_701C10) 1988; 17 Patzek (2023071212451521900_JOCES_92_4_701C24) 1986; 102 Rodman (2023071212451521900_JOCES_92_4_701C25) 1986; 102 Glickman (2023071212451521900_JOCES_92_4_701C11) 1983; 97 Tougard (2023071212451521900_JOCES_92_4_701C29) 1980; 158 Ottosen (2023071212451521900_JOCES_92_4_701C22) 1980; 152 Oliver (2023071212451521900_JOCES_92_4_701C21) 1981; 23 Snider (2023071212451521900_JOCES_92_4_701C28) 1986; 103 Yuan (2023071212451521900_JOCES_92_4_701C34) 1987; 105 Henkart (2023071212451521900_JOCES_92_4_701C14) 1985; 3 Van Dyke (2023071212451521900_JOCES_92_4_701C31) 1984; 4 Ward (2023071212451521900_JOCES_92_4_701C32) 1983; 111 Goochee (2023071212451521900_JOCES_92_4_701C12) 1980; 7 Graham (2023071212451521900_JOCES_92_4_701C13) 1966; 14 Consolazione (2023071212451521900_JOCES_92_4_701C5) 1981; 29 Ohkuma (2023071212451521900_JOCES_92_4_701C20) 1978; 75 Tycko (2023071212451521900_JOCES_92_4_701C30) 1982; 28 Snider (2023071212451521900_JOCES_92_4_701C27) 1985; 100 Johnson (2023071212451521900_JOCES_92_4_701C16) 1976; 251 Marsh (2023071212451521900_JOCES_92_4_701C18) 1986; 83 Forgac (2023071212451521900_JOCES_92_4_701C9) 1983; 80 Patzak (2023071212451521900_JOCES_92_4_701C23) 1984; 98 Mclean (2023071212451521900_JOCES_92_4_701C19) 1974; 22 |
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